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@article{1392410,
author = {Hlaváčová, Miroslava and Olejníčková, Veronika and Ronzhina, M. and Stračina, Tibor and Janoušek, O. and Nováková, Marie and Babula, Petr and Kolářová, J. and Provazník, I. and Paulová, Hana},
article_location = {Praha},
article_number = {4},
keywords = {Rabbit isolated heart; LV mass; Global ischemia; Electrogram; 4-hydroxy-2-nonenal},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {Tolerance of isolated rabbit hearts to short ischemic periods is affected by increased LV mass fraction},
volume = {66},
year = {2017}
}
TY - JOUR
ID - 1392410
AU - Hlaváčová, Miroslava - Olejníčková, Veronika - Ronzhina, M. - Stračina, Tibor - Janoušek, O. - Nováková, Marie - Babula, Petr - Kolářová, J. - Provazník, I. - Paulová, Hana
PY - 2017
TI - Tolerance of isolated rabbit hearts to short ischemic periods is affected by increased LV mass fraction
JF - Physiological research
VL - 66
IS - 4
SP - 581-589
EP - 581-589
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Rabbit isolated heart
KW - LV mass
KW - Global ischemia
KW - Electrogram
KW - 4-hydroxy-2-nonenal
N2 - Hypertrophied hearts are known for increased risk of arrhythmias and are linked with reduced ischemic tolerance. However, still little is known about state characterized only by increased left ventricle (LV) mass fraction. Seventeen isolated rabbit hearts with various LV mass were divided into two groups according to LV weight/heart weight ratio (LVW/HW ratio), namely group H and L (with higher and lower LVW/HW ratio, respectively) and underwent three short cycles of global ischemia and reperfusion. The differences in electrogram (heart rate, QRSmax, mean number, onset and dominant form of ventricular premature beats) and in biochemical markers of myocardial injury (creatine kinase, lactate dehydrogenase – LDH) and lipid peroxidation (4-hydroxy-2-nonenal – 4-HNE) were studied. As compared to group L, hearts in group H exhibited lower tolerance to ischemia expressed as higher incidence and severity of arrhythmias in the first ischemic period as well as increase of LDH and 4-HNE after the first reperfusion. In the third cycle of ischemia-reperfusion, the preconditioning effect was observed in both electrophysiological parameters and LDH release in group H. Our results showed consistent trends when comparing changes in electrograms and biochemical markers. Moreover, 4-HNE seems to be good potential parameter of moderate membrane alteration following ischemia-reperfusion injury.
ER -
HLAVÁČOVÁ, Miroslava, Veronika OLEJNÍČKOVÁ, M. RONZHINA, Tibor STRAČINA, O. JANOUŠEK, Marie NOVÁKOVÁ, Petr BABULA, J. KOLÁŘOVÁ, I. PROVAZNÍK and Hana PAULOVÁ. Tolerance of isolated rabbit hearts to short ischemic periods is affected by increased LV mass fraction. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2017, vol.~66, No~4, p.~581-589. ISSN~0862-8408.
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