| KOSINOVÁ, Martina, Petr ŠTOURAČ, Milan ADAMUS, Dagmar SEIDLOVÁ, Tomáš PAVLÍK, Petr JANKŮ, Ivo KŘIKAVA, Zdeněk MROZEK, Martin PROCHÁZKA, Jozef KLUČKA, Roman ŠTOUDEK, Ivana BÁRTÍKOVÁ, Hana HARAZIM, Hana ROBOTKOVÁ, Karel HEJDUK, Zuzana HODICKÁ, Martina KIRCHNEROVA, Jana FRANČÁKOVÁ, Lenka OBARE PYSZKOVÁ, Jarmila HLOŽKOVÁ and Pavel ŠEVČÍK. Rocuronium versus suxamethonium for rapid sequence induction of general anaesthesia for caesarean section: influence on neonatal outcomes. International Journal of Obstetric Anesthesia. Oxford: Elsevier Science, 2017, vol. 32, NOV 2017, p. 4-10. ISSN 0959-289X. Available from: https://dx.doi.org/10.1016/j.ijoa.2017.05.001. |
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@article{1393109,
author = {Kosinová, Martina and Štourač, Petr and Adamus, Milan and Seidlová, Dagmar and Pavlík, Tomáš and Janků, Petr and Křikava, Ivo and Mrozek, Zdeněk and Procházka, Martin and Klučka, Jozef and Štoudek, Roman and Bártíková, Ivana and Harazim, Hana and Robotková, Hana and Hejduk, Karel and Hodická, Zuzana and Kirchnerova, Martina and Frančáková, Jana and Obare Pyszková, Lenka and Hložková, Jarmila and Ševčík, Pavel},
article_location = {Oxford},
article_number = {NOV 2017},
doi = {http://dx.doi.org/10.1016/j.ijoa.2017.05.001},
keywords = {Rocuronium; Suxamethonium; Caesarean section; Neonatal outcome; Apgar score},
language = {eng},
issn = {0959-289X},
journal = {International Journal of Obstetric Anesthesia},
title = {Rocuronium versus suxamethonium for rapid sequence induction of general anaesthesia for caesarean section: influence on neonatal outcomes},
volume = {32},
year = {2017}
}
TY - JOUR
ID - 1393109
AU - Kosinová, Martina - Štourač, Petr - Adamus, Milan - Seidlová, Dagmar - Pavlík, Tomáš - Janků, Petr - Křikava, Ivo - Mrozek, Zdeněk - Procházka, Martin - Klučka, Jozef - Štoudek, Roman - Bártíková, Ivana - Harazim, Hana - Robotková, Hana - Hejduk, Karel - Hodická, Zuzana - Kirchnerova, Martina - Frančáková, Jana - Obare Pyszková, Lenka - Hložková, Jarmila - Ševčík, Pavel
PY - 2017
TI - Rocuronium versus suxamethonium for rapid sequence induction of general anaesthesia for caesarean section: influence on neonatal outcomes
JF - International Journal of Obstetric Anesthesia
VL - 32
IS - NOV 2017
SP - 4-10
EP - 4-10
PB - Elsevier Science
SN - 0959289X
KW - Rocuronium
KW - Suxamethonium
KW - Caesarean section
KW - Neonatal outcome
KW - Apgar score
N2 - BACKGROUND: In a previous study we compared rocuronium and suxamethonium for rapid-sequence induction of general anaesthesia for caesarean section and found no difference in maternal outcome. There was however, a significant difference in Apgar scores. As this was a secondary outcome, we extended the study to explore this finding on a larger sample. METHODS: We included 488 parturients of whom 240 were women from the original study. Women were randomly assigned to receive either rocuronium 1mg/kg (ROC n=245) or suxamethonium 1mg/kg (SUX n=243) after propofol 2mg/kg. Anaesthesia was maintained with up to 50% nitrous oxide and up to one minimum alveolar concentration of sevoflurane until the umbilical cord was clamped. We compared neonatal outcome using Apgar scores and umbilical cord blood gases. RESULTS: Data were analysed for 525 newborns (ROC n=263vs. SUX n=262). There was a statistically significant difference in the proportion of Apgar scores <7 at 1min (ROC 17.5% vs. SUX 10.3%, P=0.023) but no difference at 5min (ROC 8% vs. SUX 4.2%, P=0.1) or 10min (ROC 3.0% vs. SUX 1.9%, P=0.58). There was no difference between groups in other measured outcomes. CONCLUSION: The use of rocuronium was associated with lower Apgar scores at 1min compared with suxamethonium. The clinical significance of this is unclear and warrants further investigation.
ER -
KOSINOVÁ, Martina, Petr ŠTOURAČ, Milan ADAMUS, Dagmar SEIDLOVÁ, Tomáš PAVLÍK, Petr JANKŮ, Ivo KŘIKAVA, Zdeněk MROZEK, Martin PROCHÁZKA, Jozef KLUČKA, Roman ŠTOUDEK, Ivana BÁRTÍKOVÁ, Hana HARAZIM, Hana ROBOTKOVÁ, Karel HEJDUK, Zuzana HODICKÁ, Martina KIRCHNEROVA, Jana FRANČÁKOVÁ, Lenka OBARE PYSZKOVÁ, Jarmila HLOŽKOVÁ and Pavel ŠEVČÍK. Rocuronium versus suxamethonium for rapid sequence induction of general anaesthesia for caesarean section: influence on neonatal outcomes. \textit{International Journal of Obstetric Anesthesia}. Oxford: Elsevier Science, 2017, vol.~32, NOV 2017, p.~4-10. ISSN~0959-289X. Available from: https://dx.doi.org/10.1016/j.ijoa.2017.05.001.
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