J 2017

Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease

SYRIMI, Zoe Joanna, Lubomír VOJTÍŠEK, Ilona ELIÁŠOVÁ, Jana VÍŠKOVÁ, Alena SVÁTKOVÁ et. al.

Basic information

Original name

Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease

Authors

SYRIMI, Zoe Joanna (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Jana VÍŠKOVÁ (203 Czech Republic, belonging to the institution), Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neural Transmission, Wien, SPRINGER WIEN, 2017, 0300-9564

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.779

RIV identification code

RIV/00216224:14110/17:00095668

Organization unit

Faculty of Medicine

DOI

UT WoS

000399891600004

Keywords in English

Parkinson's disease; Arterial spin labelling; Perfusion; Cognitive performance

Tags

Tags

International impact, Reviewed
Změněno: 12/3/2018 15:55, Soňa Böhmová

Abstract

V originále

While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years +/- 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years +/- 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.

Links

LQ1601, research and development project
Name: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
NV15-33854A, research and development project
Name: Efekt intenzivní tanečně-pohybové intervence na kognitivní funkce a změny mozkové plasticity zdravých seniorů a pacientů s mírnou kognitivní poruchou