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@article{1394005,
author = {Kadaňka, Zdeněk and Adamová, Blanka and Keřkovský, Miloš and Kadaňka, Zdeněk and Dušek, Ladislav and Jurová, Barbora and Vlčková, Eva and Bednařík, Josef},
article_location = {Hoboken},
article_number = {9},
doi = {http://dx.doi.org/10.1002/brb3.797},
keywords = {cervical radiculopathy; degenerative cervical myelopathy; magnetic resonance imaging; nonmyelopathic degenerative cervical cord compression; predictive model},
language = {eng},
issn = {2162-3279},
journal = {Brain and Behavior},
title = {Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression},
volume = {7},
year = {2017}
}
TY - JOUR
ID - 1394005
AU - Kadaňka, Zdeněk - Adamová, Blanka - Keřkovský, Miloš - Kadaňka, Zdeněk - Dušek, Ladislav - Jurová, Barbora - Vlčková, Eva - Bednařík, Josef
PY - 2017
TI - Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression
JF - Brain and Behavior
VL - 7
IS - 9
SP - 1-10
EP - 1-10
PB - John Wiley and Sons Inc.
SN - 21623279
KW - cervical radiculopathy
KW - degenerative cervical myelopathy
KW - magnetic resonance imaging
KW - nonmyelopathic degenerative cervical cord compression
KW - predictive model
N2 - Objectives: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). Material and Methods: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59years, range 40-79years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2years (median duration 3years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry. Results: Clinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run-time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross-sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross-sectional area (CSA)70.1mm(2), and compression ratio (CR)0.4 were the only independent significant predictors for progression into symptomatic myelopathy. Conclusions: In addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.
ER -
KADAŇKA, Zdeněk, Blanka ADAMOVÁ, Miloš KEŘKOVSKÝ, Zdeněk KADAŇKA, Ladislav DUŠEK, Barbora JUROVÁ, Eva VLČKOVÁ and Josef BEDNAŘÍK. Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2017, vol.~7, No~9, p.~1-10. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.797.
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