Predictors of symptomatic myelopathy in degenerative cervical
spinal cord compression

J 2017

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

KADAŇKA, Zdeněk, Blanka ADAMOVÁ, Miloš KEŘKOVSKÝ, Zdeněk KADAŇKA, Ladislav DUŠEK et. al.

Basic information

Original name

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

Authors

KADAŇKA, Zdeněk (203 Czech Republic, guarantor), Blanka ADAMOVÁ (203 Czech Republic, belonging to the institution), Miloš KEŘKOVSKÝ (203 Czech Republic), Zdeněk KADAŇKA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Barbora JUROVÁ (203 Czech Republic), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2017, 2162-3279

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.219

RIV identification code

RIV/00216224:14110/17:00095669

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/brb3.797

UT WoS

000411368500027

Keywords in English

cervical radiculopathy; degenerative cervical myelopathy; magnetic resonance imaging; nonmyelopathic degenerative cervical cord compression; predictive model

Abstract

V originále

Objectives: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). Material and Methods: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59years, range 40-79years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2years (median duration 3years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry. Results: Clinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run-time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross-sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross-sectional area (CSA)70.1mm(2), and compression ratio (CR)0.4 were the only independent significant predictors for progression into symptomatic myelopathy. Conclusions: In addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.

Links

NT13449, research and development project

Name: Spondylogenní komprese krční míchy - prevalence, diagnostika a prognóza

Citovat

KADAŇKA, Zdeněk, Blanka ADAMOVÁ, Miloš KEŘKOVSKÝ, Zdeněk KADAŇKA, Ladislav DUŠEK, Barbora JUROVÁ, Eva VLČKOVÁ and Josef BEDNAŘÍK. Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression. Brain and Behavior. Hoboken: John Wiley and Sons Inc., 2017, vol. 7, No 9, p. 1-10. ISSN 2162-3279. Available from: https://dx.doi.org/10.1002/brb3.797.

@article{1394005,
   author = {Kadaňka, Zdeněk and Adamová, Blanka and Keřkovský, Miloš and Kadaňka, Zdeněk and Dušek, Ladislav and Jurová, Barbora and Vlčková, Eva and Bednařík, Josef},
   article_location = {Hoboken},
   article_number = {9},
   doi = {http://dx.doi.org/10.1002/brb3.797},
   keywords = {cervical radiculopathy; degenerative cervical myelopathy; magnetic resonance imaging; nonmyelopathic degenerative cervical cord compression; predictive model},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression},
   volume = {7},
   year = {2017}
}

TY  - JOUR
ID  - 1394005
AU  - Kadaňka, Zdeněk - Adamová, Blanka - Keřkovský, Miloš - Kadaňka, Zdeněk - Dušek, Ladislav - Jurová, Barbora - Vlčková, Eva - Bednařík, Josef
PY  - 2017
TI  - Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression
JF  - Brain and Behavior
VL  - 7
IS  - 9
SP  - 1-10
EP  - 1-10
PB  - John Wiley and Sons Inc.
SN  - 21623279
KW  - cervical radiculopathy
KW  - degenerative cervical myelopathy
KW  - magnetic resonance imaging
KW  - nonmyelopathic degenerative cervical cord compression
KW  - predictive model
N2  - Objectives: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). Material and Methods: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59years, range 40-79years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2years (median duration 3years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry. Results: Clinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run-time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross-sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross-sectional area (CSA)70.1mm(2), and compression ratio (CR)0.4 were the only independent significant predictors for progression into symptomatic myelopathy. Conclusions: In addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.
ER  -

KADAŇKA, Zdeněk, Blanka ADAMOVÁ, Miloš KEŘKOVSKÝ, Zdeněk KADAŇKA, Ladislav DUŠEK, Barbora JUROVÁ, Eva VLČKOVÁ and Josef BEDNAŘÍK. Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2017, vol.~7, No~9, p.~1-10. ISSN~2162-3279. Available from: https://dx.doi.org/10.1002/brb3.797.

Detailed Information on Publication Record