| HOFER, M., Z. HOFEROVA, Ladislav DUŠEK, Karel SOUČEK and A. GRUZDEV. Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice. Physiological research. Praha: Fyziologický ústav AV ČR, 2017, vol. 66, No 4, p. 673-676. ISSN 0862-8408. |
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@article{1394341,
author = {Hofer, M. and Hoferova, Z. and Dušek, Ladislav and Souček, Karel and Gruzdev, A.},
article_location = {Praha},
article_number = {4},
keywords = {Cyclooxygenase-2; COX-2 knock-out mice; Hematopoiesis; Ionizing radiation; Post-irradiation inflammation},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice},
volume = {66},
year = {2017}
}
TY - JOUR
ID - 1394341
AU - Hofer, M. - Hoferova, Z. - Dušek, Ladislav - Souček, Karel - Gruzdev, A.
PY - 2017
TI - Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice
JF - Physiological research
VL - 66
IS - 4
SP - 673-676
EP - 673-676
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Cyclooxygenase-2
KW - COX-2 knock-out mice
KW - Hematopoiesis
KW - Ionizing radiation
KW - Post-irradiation inflammation
N2 - We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.
ER -
HOFER, M., Z. HOFEROVA, Ladislav DUŠEK, Karel SOUČEK and A. GRUZDEV. Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2017, vol.~66, No~4, p.~673-676. ISSN~0862-8408.
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