Detailed Information on Publication Record
2017
Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice
HOFER, M., Z. HOFEROVA, Ladislav DUŠEK, Karel SOUČEK, A. GRUZDEV et. al.Basic information
Original name
Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice
Authors
HOFER, M. (203 Czech Republic), Z. HOFEROVA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, guarantor, belonging to the institution), Karel SOUČEK (203 Czech Republic, belonging to the institution) and A. GRUZDEV (840 United States of America)
Edition
Physiological research, Praha, Fyziologický ústav AV ČR, 2017, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.324
RIV identification code
RIV/00216224:14110/17:00095137
Organization unit
Faculty of Medicine
UT WoS
000412736000013
Keywords in English
Cyclooxygenase-2; COX-2 knock-out mice; Hematopoiesis; Ionizing radiation; Post-irradiation inflammation
Tags
International impact, Reviewed
Změněno: 20/3/2018 14:11, Soňa Böhmová
Abstract
V originále
We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.
Links
| GA16-12454S, research and development project |
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