Importance of Preoperative Knowledge of the Biomarker HE4 in
Early-stage Endometrial Cancer Regarding Surgical Management

J 2017

Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management

PRESL, J., Petra OVESNÁ, Z. NOVOTNY, P. VLASAK, J. BOUDA et. al.

Basic information

Original name

Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management

Authors

PRESL, J. (203 Czech Republic), Petra OVESNÁ (203 Czech Republic, guarantor, belonging to the institution), Z. NOVOTNY (203 Czech Republic), P. VLASAK (203 Czech Republic), J. BOUDA (203 Czech Republic), J. KOSTUN (203 Czech Republic), O. TOPOLCAN (203 Czech Republic), R. KUCERA (203 Czech Republic), Markéta BEDNAŘÍKOVÁ (203 Czech Republic, belonging to the institution) and Vít WEINBERGER (203 Czech Republic, belonging to the institution)

Edition

Anticancer Research, Athens, The International Institute of Anticancer Research, 2017, 0250-7005

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.865

RIV identification code

RIV/00216224:14110/17:00098150

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.21873/anticanres.11619

UT WoS

000402173300069

Keywords in English

CA125; HE4; endometrial cancer; preoperative staging

Abstract

V originále

Aim: To analyze the utility of HE4 assessment in preoperative management of patients with early-stage endometrial cancer for stratification into low-risk and high-risk groups. Patients and Methods: The following data were prospectively collected from patients operated for endometrial cancer from 05/2012 till 9/2016; age, HE4, CA125, expert ultrasound examination of the pelvis, histotype, grade, FIGO stage. Results: In total, 124 patients were enrolled. A cut-off of >= 113 pmol/l HE4 demonstrated 40.3% sensitivity and 83.9% specificity for detection of high-risk patients. Correlations of HE4 with age (p<0.001), depth of myometrial invasion (p=0.001), clinical stage of the disease according to ultrasound - T1a vs. T1b (63.6 pmol/l vs. 110.6 pmol/l, p<0.001) were found. However, no correlation of HE4 with lymph node invasion (p=0.07) and tumor grade (p=0.212) was identified. Conclusion: HE4 levels correspond to clinical and FIGO stage of the disease. The sensitivity and specificity does not reach the transvaginal ultrasound results in preoperative assessment of the extent of the disease. Combination of HE4 with ultrasound does not improve the stratification of patients into low-risk and high-risk groups. Preoperative assessment of HE4 is useful providing no imaging method is available.

Citovat

PRESL, J., Petra OVESNÁ, Z. NOVOTNY, P. VLASAK, J. BOUDA, J. KOSTUN, O. TOPOLCAN, R. KUCERA, Markéta BEDNAŘÍKOVÁ and Vít WEINBERGER. Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management. Anticancer Research. Athens: The International Institute of Anticancer Research, 2017, vol. 37, No 5, p. 2697-2702. ISSN 0250-7005. Available from: https://dx.doi.org/10.21873/anticanres.11619.

@article{1394342,
   author = {Presl, J. and Ovesná, Petra and Novotny, Z. and Vlasak, P. and Bouda, J. and Kostun, J. and Topolcan, O. and Kucera, R. and Bednaříková, Markéta and Weinberger, Vít},
   article_location = {Athens},
   article_number = {5},
   doi = {http://dx.doi.org/10.21873/anticanres.11619},
   keywords = {CA125; HE4; endometrial cancer; preoperative staging},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management},
   volume = {37},
   year = {2017}
}

TY  - JOUR
ID  - 1394342
AU  - Presl, J. - Ovesná, Petra - Novotny, Z. - Vlasak, P. - Bouda, J. - Kostun, J. - Topolcan, O. - Kucera, R. - Bednaříková, Markéta - Weinberger, Vít
PY  - 2017
TI  - Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management
JF  - Anticancer Research
VL  - 37
IS  - 5
SP  - 2697-2702
EP  - 2697-2702
PB  - The International Institute of Anticancer Research
SN  - 02507005
KW  - CA125
KW  - HE4
KW  - endometrial cancer
KW  - preoperative staging
N2  - Aim: To analyze the utility of HE4 assessment in preoperative management of patients with early-stage endometrial cancer for stratification into low-risk and high-risk groups. Patients and Methods: The following data were prospectively collected from patients operated for endometrial cancer from 05/2012 till 9/2016; age, HE4, CA125, expert ultrasound examination of the pelvis, histotype, grade, FIGO stage. Results: In total, 124 patients were enrolled. A cut-off of >= 113 pmol/l HE4 demonstrated 40.3% sensitivity and 83.9% specificity for detection of high-risk patients. Correlations of HE4 with age (p<0.001), depth of myometrial invasion (p=0.001), clinical stage of the disease according to ultrasound - T1a vs. T1b (63.6 pmol/l vs. 110.6 pmol/l, p<0.001) were found. However, no correlation of HE4 with lymph node invasion (p=0.07) and tumor grade (p=0.212) was identified. Conclusion: HE4 levels correspond to clinical and FIGO stage of the disease. The sensitivity and specificity does not reach the transvaginal ultrasound results in preoperative assessment of the extent of the disease. Combination of HE4 with ultrasound does not improve the stratification of patients into low-risk and high-risk groups. Preoperative assessment of HE4 is useful providing no imaging method is available.
ER  -

PRESL, J., Petra OVESNÁ, Z. NOVOTNY, P. VLASAK, J. BOUDA, J. KOSTUN, O. TOPOLCAN, R. KUCERA, Markéta BEDNAŘÍKOVÁ and Vít WEINBERGER. Importance of Preoperative Knowledge of the Biomarker HE4 in Early-stage Endometrial Cancer Regarding Surgical Management. \textit{Anticancer Research}. Athens: The International Institute of Anticancer Research, 2017, vol.~37, No~5, p.~2697-2702. ISSN~0250-7005. Available from: https://dx.doi.org/10.21873/anticanres.11619.

Detailed Information on Publication Record