Heart rate is a useful marker of adherence to beta-blocker
treatment in hypertension

J 2017

Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension

KOCIANOVA, E., J. VACLAVIK, J. TOMKOVA, P. ONDRA, Jiří JARKOVSKÝ et. al.

Basic information

Original name

Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension

Authors

KOCIANOVA, E. (203 Czech Republic), J. VACLAVIK (203 Czech Republic), J. TOMKOVA (203 Czech Republic), P. ONDRA (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution), T. VACLAVIK (203 Czech Republic), M. KAMASOVA (203 Czech Republic) and M. TABORSKY (203 Czech Republic)

Edition

Blood Pressure, London, INFORMA HEALTHCARE, 2017, 0803-7051

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.107

RIV identification code

RIV/00216224:14110/17:00098155

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1080/08037051.2017.1346458

UT WoS

000407613100009

Keywords in English

Adherence; beta blockers; compliance; resistant hypertension; drug level monitoring

Abstract

V originále

Objectives: Suboptimal medication adherence is common among patients with hypertension. Measurements of plasma or urinary levels of antihypertensive drugs are useful, but not widely available. The aim of our study was to investigate the relation of patients' heart rates to their serum beta-blocker levels.Methods: We correlated 220 measurements of serum beta-blocker levels in 106 patients with apparently resistant hypertension to their corresponding office heart rate. A significant proportion, 44.6% of patients, were non-adherent to beta-blocker treatment according to serum level measurement. Non-adherent patients had significantly higher heart rates (80.9 vs. 66.6 bpm, p<.001), systolic (157.4 vs. 147.0mm Hg, p=.002) and diastolic blood pressure (91.1 vs. 87.2mm Hg, p=.041) in comparison to adherent patients.Results: Heart rate above 75.5 beats per minute predicted non-adherence to beta-blocker treatment with a sensitivity of 62.5%, specificity 86.8% and AUC ROC 0.802 (p<.001). Higher heart rate cutoff might be applicable for nebivolol but was not determined due to the low number of patients treated with nebivolol.Conclusions: We concluded that heart rate was shown to be a good predictor of non-adherence to beta-blocker treatment, and might become a quick and easy measure to determine patient adherence in hypertensive patients.

Citovat

KOCIANOVA, E., J. VACLAVIK, J. TOMKOVA, P. ONDRA, Jiří JARKOVSKÝ, Klára BENEŠOVÁ, T. VACLAVIK, M. KAMASOVA and M. TABORSKY. Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension. Blood Pressure. London: INFORMA HEALTHCARE, 2017, vol. 26, No 5, p. 311-318. ISSN 0803-7051. Available from: https://dx.doi.org/10.1080/08037051.2017.1346458.

@article{1394348,
   author = {Kocianova, E. and Vaclavik, J. and Tomkova, J. and Ondra, P. and Jarkovský, Jiří and Benešová, Klára and Vaclavik, T. and Kamasova, M. and Taborsky, M.},
   article_location = {London},
   article_number = {5},
   doi = {http://dx.doi.org/10.1080/08037051.2017.1346458},
   keywords = {Adherence; beta blockers; compliance; resistant hypertension; drug level monitoring},
   language = {eng},
   issn = {0803-7051},
   journal = {Blood Pressure},
   title = {Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension},
   url = {http://www.tandfonline.com/doi/full/10.1080/08037051.2017.1346458?scroll=top&needAccess=true},
   volume = {26},
   year = {2017}
}

TY  - JOUR
ID  - 1394348
AU  - Kocianova, E. - Vaclavik, J. - Tomkova, J. - Ondra, P. - Jarkovský, Jiří - Benešová, Klára - Vaclavik, T. - Kamasova, M. - Taborsky, M.
PY  - 2017
TI  - Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension
JF  - Blood Pressure
VL  - 26
IS  - 5
SP  - 311-318
EP  - 311-318
PB  - INFORMA HEALTHCARE
SN  - 08037051
KW  - Adherence
KW  - beta blockers
KW  - compliance
KW  - resistant hypertension
KW  - drug level monitoring
UR  - http://www.tandfonline.com/doi/full/10.1080/08037051.2017.1346458?scroll=top&needAccess=true
N2  - Objectives: Suboptimal medication adherence is common among patients with hypertension. Measurements of plasma or urinary levels of antihypertensive drugs are useful, but not widely available. The aim of our study was to investigate the relation of patients' heart rates to their serum beta-blocker levels.Methods: We correlated 220 measurements of serum beta-blocker levels in 106 patients with apparently resistant hypertension to their corresponding office heart rate. A significant proportion, 44.6% of patients, were non-adherent to beta-blocker treatment according to serum level measurement. Non-adherent patients had significantly higher heart rates (80.9 vs. 66.6 bpm, p<.001), systolic (157.4 vs. 147.0mm Hg, p=.002) and diastolic blood pressure (91.1 vs. 87.2mm Hg, p=.041) in comparison to adherent patients.Results: Heart rate above 75.5 beats per minute predicted non-adherence to beta-blocker treatment with a sensitivity of 62.5%, specificity 86.8% and AUC ROC 0.802 (p<.001). Higher heart rate cutoff might be applicable for nebivolol but was not determined due to the low number of patients treated with nebivolol.Conclusions: We concluded that heart rate was shown to be a good predictor of non-adherence to beta-blocker treatment, and might become a quick and easy measure to determine patient adherence in hypertensive patients.
ER  -

KOCIANOVA, E., J. VACLAVIK, J. TOMKOVA, P. ONDRA, Jiří JARKOVSKÝ, Klára BENEŠOVÁ, T. VACLAVIK, M. KAMASOVA and M. TABORSKY. Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension. \textit{Blood Pressure}. London: INFORMA HEALTHCARE, 2017, vol.~26, No~5, p.~311-318. ISSN~0803-7051. Available from: https://dx.doi.org/10.1080/08037051.2017.1346458.

Detailed Information on Publication Record