KOCIANOVA, E., J. VACLAVIK, J. TOMKOVA, P. ONDRA, Jiří JARKOVSKÝ, Klára BENEŠOVÁ, T. VACLAVIK, M. KAMASOVA and M. TABORSKY. Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension. Blood Pressure. London: INFORMA HEALTHCARE, 2017, vol. 26, No 5, p. 311-318. ISSN 0803-7051. Available from: https://dx.doi.org/10.1080/08037051.2017.1346458.
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Basic information
Original name Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension
Authors KOCIANOVA, E. (203 Czech Republic), J. VACLAVIK (203 Czech Republic), J. TOMKOVA (203 Czech Republic), P. ONDRA (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution), T. VACLAVIK (203 Czech Republic), M. KAMASOVA (203 Czech Republic) and M. TABORSKY (203 Czech Republic).
Edition Blood Pressure, London, INFORMA HEALTHCARE, 2017, 0803-7051.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.107
RIV identification code RIV/00216224:14110/17:00098155
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1080/08037051.2017.1346458
UT WoS 000407613100009
Keywords in English Adherence; beta blockers; compliance; resistant hypertension; drug level monitoring
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 20/3/2018 16:39.
Abstract
Objectives: Suboptimal medication adherence is common among patients with hypertension. Measurements of plasma or urinary levels of antihypertensive drugs are useful, but not widely available. The aim of our study was to investigate the relation of patients' heart rates to their serum beta-blocker levels.Methods: We correlated 220 measurements of serum beta-blocker levels in 106 patients with apparently resistant hypertension to their corresponding office heart rate. A significant proportion, 44.6% of patients, were non-adherent to beta-blocker treatment according to serum level measurement. Non-adherent patients had significantly higher heart rates (80.9 vs. 66.6 bpm, p<.001), systolic (157.4 vs. 147.0mm Hg, p=.002) and diastolic blood pressure (91.1 vs. 87.2mm Hg, p=.041) in comparison to adherent patients.Results: Heart rate above 75.5 beats per minute predicted non-adherence to beta-blocker treatment with a sensitivity of 62.5%, specificity 86.8% and AUC ROC 0.802 (p<.001). Higher heart rate cutoff might be applicable for nebivolol but was not determined due to the low number of patients treated with nebivolol.Conclusions: We concluded that heart rate was shown to be a good predictor of non-adherence to beta-blocker treatment, and might become a quick and easy measure to determine patient adherence in hypertensive patients.
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