Increased age-adjusted hazard of death associated with a common
single nucleotide polymorphism of the human RAD52 gene in a
cardiovascular cohort

J 2017

Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort

LENÁRT, Peter, Filip ZLÁMAL, Jan MÁCHAL, Ota HLINOMAZ, Ladislav GROCH et. al.

Basic information

Original name

Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort

Authors

LENÁRT, Peter (703 Slovakia, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Ota HLINOMAZ (203 Czech Republic), Ladislav GROCH (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

Mechanisms of Ageing and Development, Clare, Elsevier Ireland Ltd. 2017, 0047-6374

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.748

RIV identification code

RIV/00216224:14110/17:00098203

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.mad.2017.10.003

UT WoS

000414108500007

Keywords in English

Aging; DNA damage; DNA damage response; Double strand breaks; Longitudinal study; RAD52

Abstract

V originále

Aging may be characterized as the progressive increase of the risk of death caused by a decrease of almost all bodily functions. While a great number of model organism studies have established the role of DNA double strand breaks (DSBs) as one of the main causes of aging, few studies have examined whether common polymorphisms in human DSB repair genes influence aging and mortality. More importantly, to the best of our knowledge, no longitudinal study has thus far examined the link between polymorphisms in DSB repair and the risk of death. This longitudinal study thus analyses whether four common polymorphisms (rs2155209, rs7963551, rs17105278, rs2735383) in four selected DSB repair genes (MRE11A, RAD52, RAD51B, NBS1) influence the hazard of age-adjusted death in a cohort of patients with typical symptoms of ischemic heart disease. The results have shown that rs7963551 G/T heterozygotes exhibit a significantly increased hazard of death when compared with the combined GG and TT homozygotes (HR = 1.42, 95% CI: 1.06–1.91, p = 0.018). This study indicates that the SNP affecting efficiency of DSB repair may influence aging in humans.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

MUNI/C/1066/2015, interní kód MU

Name: Dvojvláknové zlomy u jedinců s velmi vysokou délkou života a možný vztah ke stravovacím návykům

Investor: Masaryk University, Rector's Program

Citovat

LENÁRT, Peter, Filip ZLÁMAL, Jan MÁCHAL, Ota HLINOMAZ, Ladislav GROCH and Julie BIENERTOVÁ VAŠKŮ. Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. Mechanisms of Ageing and Development. Clare: Elsevier Ireland Ltd., 2017, vol. 167, OCT 2017, p. 56-63. ISSN 0047-6374. Available from: https://dx.doi.org/10.1016/j.mad.2017.10.003.

@article{1395001,
   author = {Lenárt, Peter and Zlámal, Filip and Máchal, Jan and Hlinomaz, Ota and Groch, Ladislav and Bienertová Vašků, Julie},
   article_location = {Clare},
   article_number = {OCT 2017},
   doi = {http://dx.doi.org/10.1016/j.mad.2017.10.003},
   keywords = {Aging; DNA damage; DNA damage response; Double strand breaks; Longitudinal study; RAD52},
   language = {eng},
   issn = {0047-6374},
   journal = {Mechanisms of Ageing and Development},
   title = {Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort},
   volume = {167},
   year = {2017}
}

TY  - JOUR
ID  - 1395001
AU  - Lenárt, Peter - Zlámal, Filip - Máchal, Jan - Hlinomaz, Ota - Groch, Ladislav - Bienertová Vašků, Julie
PY  - 2017
TI  - Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort
JF  - Mechanisms of Ageing and Development
VL  - 167
IS  - OCT 2017
SP  - 56-63
EP  - 56-63
PB  - Elsevier Ireland Ltd.
SN  - 00476374
KW  - Aging
KW  - DNA damage
KW  - DNA damage response
KW  - Double strand breaks
KW  - Longitudinal study
KW  - RAD52
N2  - Aging may be characterized as the progressive increase of the risk of death caused by a decrease of almost all bodily functions. While a great number of model organism studies have established the role of DNA double strand breaks (DSBs) as one of the main causes of aging, few studies have examined whether common polymorphisms in human DSB repair genes influence aging and mortality. More importantly, to the best of our knowledge, no longitudinal study has thus far examined the link between polymorphisms in DSB repair and the risk of death. This longitudinal study thus analyses whether four common polymorphisms (rs2155209, rs7963551, rs17105278, rs2735383) in four selected DSB repair genes (MRE11A, RAD52, RAD51B, NBS1) influence the hazard of age-adjusted death in a cohort of patients with typical symptoms of ischemic heart disease. The results have shown that rs7963551 G/T heterozygotes exhibit a significantly increased hazard of death when compared with the combined GG and TT homozygotes (HR = 1.42, 95% CI: 1.06–1.91, p = 0.018). This study indicates that the SNP affecting efficiency of DSB repair may influence aging in humans.
ER  -

LENÁRT, Peter, Filip ZLÁMAL, Jan MÁCHAL, Ota HLINOMAZ, Ladislav GROCH and Julie BIENERTOVÁ VAŠKŮ. Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort. \textit{Mechanisms of Ageing and Development}. Clare: Elsevier Ireland Ltd., 2017, vol.~167, OCT 2017, p.~56-63. ISSN~0047-6374. Available from: https://dx.doi.org/10.1016/j.mad.2017.10.003.

Detailed Information on Publication Record