| ČUNDRLE, Ivan, V.K. SOMERS, P. SINGH, B.D. JOHNSON, C.G. SCOTT and L.J. OLSON. Sex differences in leptin modulate ventilation in heart failure. HEART & LUNG. NEW YORK: MOSBY-ELSEVIER, 2017, vol. 46, No 3, p. 187-191. ISSN 0147-9563. Available from: https://dx.doi.org/10.1016/j.hrtlng.2017.01.008. |
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@article{1395063,
author = {Čundrle, Ivan and Somers, V.K. and Singh, P. and Johnson, B.D. and Scott, C.G. and Olson, L.J.},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.hrtlng.2017.01.008},
keywords = {Leptin; Sex differences; Exercise ventilation; Ventilatory efficiency; Brain natriuretic peptide},
language = {eng},
issn = {0147-9563},
journal = {HEART & LUNG},
title = {Sex differences in leptin modulate ventilation in heart failure},
volume = {46},
year = {2017}
}
TY - JOUR
ID - 1395063
AU - Čundrle, Ivan - Somers, V.K. - Singh, P. - Johnson, B.D. - Scott, C.G. - Olson, L.J.
PY - 2017
TI - Sex differences in leptin modulate ventilation in heart failure
JF - HEART & LUNG
VL - 46
IS - 3
SP - 187-191
EP - 187-191
PB - MOSBY-ELSEVIER
SN - 01479563
KW - Leptin
KW - Sex differences
KW - Exercise ventilation
KW - Ventilatory efficiency
KW - Brain natriuretic peptide
N2 - Background: Leptin modulates ventilation and circulating levels are higher in normal women than men. Objectives: The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. Methods: Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. Results: Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 +/- 10 vs. 25.3 +/- 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (V-E/VCO2) was higher (43 +/- 10 vs. 36 +/- 5; p < 0.01) in men. Leptin concentration was associated with peak exercise V-E/VCO2 (b = -0.35; F = 5.6; p = 0.02). Conclusion: Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive. (C) 2017 Published by Elsevier Inc.
ER -
ČUNDRLE, Ivan, V.K. SOMERS, P. SINGH, B.D. JOHNSON, C.G. SCOTT and L.J. OLSON. Sex differences in leptin modulate ventilation in heart failure. \textit{HEART \&{}amp; LUNG}. NEW YORK: MOSBY-ELSEVIER, 2017, vol.~46, No~3, p.~187-191. ISSN~0147-9563. Available from: https://dx.doi.org/10.1016/j.hrtlng.2017.01.008.
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