The connections of Wnt pathway components with cell cycle and
centrosome: side effects or a hidden logic?

J 2017

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

BRYJA, Vítězslav, Igor ČERVENKA and Lukáš ČAJÁNEK

Basic information

Original name

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

Authors

BRYJA, Vítězslav (203 Czech Republic, guarantor, belonging to the institution), Igor ČERVENKA (703 Slovakia) and Lukáš ČAJÁNEK (203 Czech Republic, belonging to the institution)

Edition

Critical Reviews in Biochemistry and Molecular Biology, Abingdon, TAYLOR & FRANCIS LTD, 2017, 1040-9238

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.279

RIV identification code

RIV/00216224:14310/17:00095167

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1080/10409238.2017.1350135

UT WoS

000416064400003

Keywords in English

Wnt; centrosome; cilium; cell cycle; crosstalk; planar cell polarity

Abstract

V originále

Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components – such as beta-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms – such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response

Links

GA15-21789S, research and development project

Name: Dishevelled - identifikace základních koordinát

Investor: Czech Science Foundation

GA17-16680S, research and development project

Name: Nové postupy pro určení aktivity dráhy planární buněčné polarity (PCP)

Investor: Czech Science Foundation

GJ16-03269Y, research and development project

Name: Tau tubulin kináza 2 v ciliogenezi: molekulární mechanismy a funkční důsledky

Investor: Czech Science Foundation

MUNI/G/1100/2016, interní kód MU

Name: Computational chemistry for Wnt signaling pathway

Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects

ROZV/24/LF/2016, interní kód MU

Name: LF - Příspěvek IP 2016

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

BRYJA, Vítězslav, Igor ČERVENKA and Lukáš ČAJÁNEK. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? Critical Reviews in Biochemistry and Molecular Biology. Abingdon: TAYLOR & FRANCIS LTD, 2017, vol. 52, No 6, p. 614-637. ISSN 1040-9238. Available from: https://dx.doi.org/10.1080/10409238.2017.1350135.

@article{1395481,
   author = {Bryja, Vítězslav and Červenka, Igor and Čajánek, Lukáš},
   article_location = {Abingdon},
   article_number = {6},
   doi = {http://dx.doi.org/10.1080/10409238.2017.1350135},
   keywords = {Wnt; centrosome; cilium; cell cycle; crosstalk; planar cell polarity},
   language = {eng},
   issn = {1040-9238},
   journal = {Critical Reviews in Biochemistry and Molecular Biology},
   title = {The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?},
   url = {http://www.tandfonline.com/doi/abs/10.1080/10409238.2017.1350135?journalCode=ibmg20},
   volume = {52},
   year = {2017}
}

TY  - JOUR
ID  - 1395481
AU  - Bryja, Vítězslav - Červenka, Igor - Čajánek, Lukáš
PY  - 2017
TI  - The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?
JF  - Critical Reviews in Biochemistry and Molecular Biology
VL  - 52
IS  - 6
SP  - 614-637
EP  - 614-637
PB  - TAYLOR & FRANCIS LTD
SN  - 10409238
KW  - Wnt
KW  - centrosome
KW  - cilium
KW  - cell cycle
KW  - crosstalk
KW  - planar cell polarity
UR  - http://www.tandfonline.com/doi/abs/10.1080/10409238.2017.1350135?journalCode=ibmg20
N2  - Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components – such as beta-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms – such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response
ER  -

BRYJA, Vítězslav, Igor ČERVENKA and Lukáš ČAJÁNEK. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? \textit{Critical Reviews in Biochemistry and Molecular Biology}. Abingdon: TAYLOR \&{} FRANCIS LTD, 2017, vol.~52, No~6, p.~614-637. ISSN~1040-9238. Available from: https://dx.doi.org/10.1080/10409238.2017.1350135.

Detailed Information on Publication Record