TUSC3: functional duality of a cancer gene

J 2018

TUSC3: functional duality of a cancer gene

VAŠÍČKOVÁ, Kateřina, Peter HORÁK and Petr VAŇHARA

Basic information

Original name

TUSC3: functional duality of a cancer gene

Authors

VAŠÍČKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Peter HORÁK (276 Germany) and Petr VAŇHARA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cellular and Molecular Life Sciences, Basel, Springer Basel AG, 2018, 1420-682X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.014

RIV identification code

RIV/00216224:14110/18:00102098

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00018-017-2660-4

UT WoS

000424876800006

Keywords in English

TUSC3; Cancer; Tumor suppressor; Oncogene; Endoplasmic reticulum; N-Glycosylation; Immunoediting

Abstract

V originále

Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum

Links

EE2.3.20.0185, research and development project

Name: Centrum analýz a modelování tkání a orgánů

MUNI/A/1369/2016, interní kód MU

Name: Zdroje pro tkáňové inženýrství 7 (Acronym: TissueENG 7)

Investor: Masaryk University, Category A

Citovat

VAŠÍČKOVÁ, Kateřina, Peter HORÁK and Petr VAŇHARA. TUSC3: functional duality of a cancer gene. Cellular and Molecular Life Sciences. Basel: Springer Basel AG, 2018, vol. 75, No 5, p. 849-857. ISSN 1420-682X. Available from: https://dx.doi.org/10.1007/s00018-017-2660-4.

@article{1395489,
   author = {Vašíčková, Kateřina and Horák, Peter and Vaňhara, Petr},
   article_location = {Basel},
   article_number = {5},
   doi = {http://dx.doi.org/10.1007/s00018-017-2660-4},
   keywords = {TUSC3; Cancer; Tumor suppressor; Oncogene; Endoplasmic reticulum; N-Glycosylation; Immunoediting},
   language = {eng},
   issn = {1420-682X},
   journal = {Cellular and Molecular Life Sciences},
   title = {TUSC3: functional duality of a cancer gene},
   url = {https://link.springer.com/article/10.1007%2Fs00018-017-2660-4},
   volume = {75},
   year = {2018}
}

TY  - JOUR
ID  - 1395489
AU  - Vašíčková, Kateřina - Horák, Peter - Vaňhara, Petr
PY  - 2018
TI  - TUSC3: functional duality of a cancer gene
JF  - Cellular and Molecular Life Sciences
VL  - 75
IS  - 5
SP  - 849-857
EP  - 849-857
PB  - Springer Basel AG
SN  - 1420682X
KW  - TUSC3
KW  - Cancer
KW  - Tumor suppressor
KW  - Oncogene
KW  - Endoplasmic reticulum
KW  - N-Glycosylation
KW  - Immunoediting
UR  - https://link.springer.com/article/10.1007%2Fs00018-017-2660-4
N2  - Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum
ER  -

VAŠÍČKOVÁ, Kateřina, Peter HORÁK and Petr VAŇHARA. TUSC3: functional duality of a cancer gene. \textit{Cellular and Molecular Life Sciences}. Basel: Springer Basel AG, 2018, vol.~75, No~5, p.~849-857. ISSN~1420-682X. Available from: https://dx.doi.org/10.1007/s00018-017-2660-4.

Detailed Information on Publication Record