J 2017

Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions

KAŠTOVSKÝ, Jakub, Petra BOŘILOVÁ LINHARTOVÁ, Kristína MUSILOVÁ, Lenka ŽÁČKOVÁ, Martina KUKLETOVÁ et. al.

Basic information

Original name

Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions

Name in Czech

BMP2/DLX3 genové polymorfizmy a zubní kaz v dočasné a stálé dentici

Authors

KAŠTOVSKÝ, Jakub (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Kristína MUSILOVÁ (203 Czech Republic, belonging to the institution), Lenka ŽÁČKOVÁ (203 Czech Republic, belonging to the institution), Martina KUKLETOVÁ (203 Czech Republic, belonging to the institution), Lubomír KUKLA (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Caries Research, Basel, Karger, 2017, 0008-6568

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.188

RIV identification code

RIV/00216224:14110/17:00095175

Organization unit

Faculty of Medicine

DOI

UT WoS

000419790800006

Keywords in English

BMP2; Case-control study; Dental caries; DLX3; Gene polymorphism

Tags

Tags

International impact, Reviewed
Změněno: 18/3/2018 17:18, Soňa Böhmová

Abstract

V originále

The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT >/= 1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft >/= 1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT >/= 9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population.

Links

EF16_013/0001761, research and development project
Name: RECETOX RI
GB14-37368G, research and development project
Name: Centrum orofaciálního vývoje a regenerace
Investor: Czech Science Foundation
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/0948/2016, interní kód MU
Name: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba
Investor: Masaryk University, Category A
NV17-30439A, research and development project
Name: Moderní biotechnologické a behaviorální přístupy ve výzkumu zubního kazu a strategie jeho prevence
ROZV/24/LF/2016, interní kód MU
Name: LF - Příspěvek IP 2016
Investor: Ministry of Education, Youth and Sports of the CR