Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment

DEISSOVÁ, Tereza, Petra BOŘILOVÁ LINHARTOVÁ, Filip MAREK, Jiří DOLINA, Adam KŘENEK, Zdeněk KALA and Lydie IZAKOVIČOVÁ HOLLÁ. Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment. In XVIII. Setkání biochemiků a molekulárních biologů, Brno. 2017. ISBN 978-80-210-8765-1.

Basic information

• Original name: Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment
• Authors: DEISSOVÁ, Tereza (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Filip MAREK (203 Czech Republic, belonging to the institution), Jiří DOLINA (203 Czech Republic, belonging to the institution), Adam KŘENEK (203 Czech Republic, belonging to the institution), Zdeněk KALA (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution).
• Edition: XVIII. Setkání biochemiků a molekulárních biologů, Brno, 2017.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30219 Gastroenterology and hepatology
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/17:00100751
• Organization unit: Faculty of Medicine
• ISBN: 978-80-210-8765-1
• Keywords in English: gastroesophageal reflux disease; forkhead box F1; major histocompatibility complex; gene polymorphism

Abstract

Background: Gastroesophageal reflux disease (GERD) is associated with functional and structural abnormalities which lead to recurrent exposure of the esophagus to acidic refluxate of gastric contents. Genetic predispositions play an important role in the etiopathogenesis of this multifactorial disease. The aim of this study was to analyze the relationship between the variants in forkhead box F1 (FOXF1) and major histocompatibility complex (MHC) selected within previous genome-wide and case-control association studies and GERD development in Czech patients. Subjects and Methods: In this case-control study, 302 patients with GERD and 124 healthy controls were genotyped for single nucleotide polymorphisms (SNPs) FOXF1 (rs9936833) and MHC (rs9257809) by TaqMan® PCR method. Diagnosis was determined based on clinical symptoms (heartburn, regurgitation), esophagogastroduodenoscopy, manometry of esophagus, 24h pH-metry and histological examination. Results: Although no association between the two studied SNPs and GERD was found, there was a marginal difference in frequencies of the CC genotype FOXF1 (rs9936833) between patients with GERD and acid reflux and healthy controls (P=0.06, OR=1.82, 95%CI=0.91- 3.66). In addition, 89% of patients with GERD suffered from acid reflux in our studied group and the surgical treatment was successful in 83% of cases. Conclusions: Our results suggest that the CC genotype may be a risk factor for acid reflux in patients with GERD. This finding is consistent with the study by Lam et al. (2016), who associated C allele with 2-fold higher risk of acid reflux. This study also confirmed that antireflux surgery is very efficacious in the treatment of GERD.

Links

• GB14-37368G, research and development project: Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

• MUNI/A/0948/2016, interní kód MU: Name: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba

Investor: Masaryk University, Category A

• ROZV/25/LF/2017, interní kód MU: Name: LF - Příspěvek na IP 2017

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects