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@article{1396180,
author = {Kojecký, Vladimír and Matous, J. and Keil, R. and Dastych, Milan and Kroupa, Radek and Zadorova, Z. and Varga, M. and Dolina, Jiří and Kment, M. and Hep, Aleš},
article_location = {New York},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s00384-017-2901-x},
keywords = {Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol},
language = {eng},
issn = {0179-1958},
journal = {International Journal of Colorectal Disease},
title = {A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial},
volume = {32},
year = {2017}
}
TY - JOUR
ID - 1396180
AU - Kojecký, Vladimír - Matous, J. - Keil, R. - Dastych, Milan - Kroupa, Radek - Zadorova, Z. - Varga, M. - Dolina, Jiří - Kment, M. - Hep, Aleš
PY - 2017
TI - A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial
JF - International Journal of Colorectal Disease
VL - 32
IS - 12
SP - 1763-1766
EP - 1763-1766
PB - Springer
SN - 01791958
KW - Ascorbic acid
KW - Colonoscopy
KW - Magnesium citrate
KW - Picosulfate sodium
KW - Polyethylene glycol
N2 - Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.
ER -
KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA, Z. ZADOROVA, M. VARGA, Jiří DOLINA, M. KMENT a Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. \textit{International Journal of Colorectal Disease}. New York: Springer, roč.~32, č.~12, s.~1763-1766. ISSN~0179-1958. doi:10.1007/s00384-017-2901-x. 2017.
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