A head-to-head comparison of 4-L polyethylene glycol and
low-volume solutions before colonoscopy: which is the best? A
multicentre, randomized trial

J 2017

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA et. al.

Basic information

Original name

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

Authors

KOJECKÝ, Vladimír (203 Czech Republic), J. MATOUS (203 Czech Republic), R. KEIL (203 Czech Republic), Milan DASTYCH (203 Czech Republic, guarantor, belonging to the institution), Radek KROUPA (203 Czech Republic, belonging to the institution), Z. ZADOROVA (203 Czech Republic), M. VARGA (203 Czech Republic), Jiří DOLINA (203 Czech Republic, belonging to the institution), M. KMENT (203 Czech Republic) and Aleš HEP (203 Czech Republic, belonging to the institution)

Edition

International Journal of Colorectal Disease, New York, Springer, 2017, 0179-1958

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.533

RIV identification code

RIV/00216224:14110/17:00098392

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00384-017-2901-x

UT WoS

000415692100014

Keywords in English

Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol

Abstract

V originále

Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.

Citovat

KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA, Z. ZADOROVA, M. VARGA, Jiří DOLINA, M. KMENT and Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. International Journal of Colorectal Disease. New York: Springer, 2017, vol. 32, No 12, p. 1763-1766. ISSN 0179-1958. Available from: https://dx.doi.org/10.1007/s00384-017-2901-x.

@article{1396180,
   author = {Kojecký, Vladimír and Matous, J. and Keil, R. and Dastych, Milan and Kroupa, Radek and Zadorova, Z. and Varga, M. and Dolina, Jiří and Kment, M. and Hep, Aleš},
   article_location = {New York},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00384-017-2901-x},
   keywords = {Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol},
   language = {eng},
   issn = {0179-1958},
   journal = {International Journal of Colorectal Disease},
   title = {A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1396180
AU  - Kojecký, Vladimír - Matous, J. - Keil, R. - Dastych, Milan - Kroupa, Radek - Zadorova, Z. - Varga, M. - Dolina, Jiří - Kment, M. - Hep, Aleš
PY  - 2017
TI  - A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial
JF  - International Journal of Colorectal Disease
VL  - 32
IS  - 12
SP  - 1763-1766
EP  - 1763-1766
PB  - Springer
SN  - 01791958
KW  - Ascorbic acid
KW  - Colonoscopy
KW  - Magnesium citrate
KW  - Picosulfate sodium
KW  - Polyethylene glycol
N2  - Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.
ER  -

KOJECKÝ, Vladimír, J. MATOUS, R. KEIL, Milan DASTYCH, Radek KROUPA, Z. ZADOROVA, M. VARGA, Jiří DOLINA, M. KMENT and Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. \textit{International Journal of Colorectal Disease}. New York: Springer, 2017, vol.~32, No~12, p.~1763-1766. ISSN~0179-1958. Available from: https://dx.doi.org/10.1007/s00384-017-2901-x.

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