J 2017

Chromatic pupillography in hemianopia patients with homonymous visual field defects

MAEDA, F., C. KELBSCH, T. STRASSER, Karolína SKORKOVSKÁ, T. PETERS et. al.

Basic information

Original name

Chromatic pupillography in hemianopia patients with homonymous visual field defects

Authors

MAEDA, F. (276 Germany), C. KELBSCH (276 Germany), T. STRASSER (276 Germany), Karolína SKORKOVSKÁ (203 Czech Republic, guarantor, belonging to the institution), T. PETERS (276 Germany), B. WILHELM (276 Germany) and H. WILHELM (276 Germany)

Edition

Graefes Archive for Clinical and Experimental Ophthalmology, New York, Springer, 2017, 0721-832X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30207 Ophthalmology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.249

RIV identification code

RIV/00216224:14110/17:00098414

Organization unit

Faculty of Medicine

DOI

UT WoS

000407587600020

Keywords in English

Pupil light reflex; Intrinsically photosensitive retinal ganglion cells; Homonymous hemianopia; Pupillary hemihypokinesia; Dorsal midbrain; Visual cortex

Tags

Tags

International impact, Reviewed
Změněno: 21/3/2018 17:50, Soňa Böhmová

Abstract

V originále

The pupil light reflex is considered to be a simple subcortical reflex. However, many studies have proven that patients with isolated occipital lesions with homonymous hemianopia show pupillary hemihypokinesia. Our hypothesis is that the afferent pupillary system consists of two pathways: one via intrinsically photosensitive retinal ganglion cells (ipRGCs), the other running through the normal RGCs via the visual cortex. The purpose of this study was to test the hypothesis of these two separate pupillomotor pathways. 12 patients (59.1 +/- 18.8 years) with homonymous hemianopia due to post-geniculate lesions of the visual pathway and 20 normal controls (58.6 +/- 12.9 years) were examined using chromatic pupillography: stimulus intensity was 28 lx corneal illumination, stimulus duration was 4.0 s, and the stimulus wavelengths were 420 +/- 20 nm (blue) and 605 +/- 20 nm (red), respectively. The examined parameters were baseline pupil diameter, latency, and relative amplitudes (absolute amplitudes compared to baseline), measured at maximal constriction, at 3 s after stimulus onset, at stimulus offset, and at 3 s and 7 s after stimulus offset. The relative amplitudes for the red stimulus were significantly smaller for hemianopia patients compared to the normal controls [maximal constriction: 35.6 +/- 5.9% (hemianopia) to 42.3 +/- 5.7% (normal); p = 0.004; 3 s after stimulus onset: p = 0.004; stimulus offset: p = 0.001]. No significant differences in any parameter were found between the two groups using the blue stimulus. The results support the hypothesis that the ipRGC pathway is mainly subcortical, whereas a second, non-ipRGC pathway via the occipital cortex exists.