Sensory phenotype and risk factors for painful diabetic
neuropathy: a cross-sectional observational study

J 2017

Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study

RAPUTOVÁ, Jana, Iva ŠROTOVÁ, Eva VLČKOVÁ, Claudia SOMMER, Nurcan ÜCEYLER et. al.

Basic information

Original name

Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study

Authors

RAPUTOVÁ, Jana (203 Czech Republic, belonging to the institution), Iva ŠROTOVÁ (203 Czech Republic, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Claudia SOMMER (276 Germany), Nurcan ÜCEYLER (276 Germany), Frank BIRKLEIN (276 Germany), Heike L. RITTNER (276 Germany), Cora REBHORN (276 Germany), Blanka ADAMOVÁ (203 Czech Republic, belonging to the institution), Ivana KOVAĽOVÁ (703 Slovakia, belonging to the institution), Eva KRÁLÍČKOVÁ NEKVAPILOVÁ (203 Czech Republic), Lucas FORER (40 Austria), Jana BĚLOBRÁDKOVÁ (203 Czech Republic), Jindřich OLŠOVSKÝ (203 Czech Republic), Pavel WEBER (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Pain, Philadelphia, Lippincott Williams & Wilkins, 2017, 0304-3959

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.559

RIV identification code

RIV/00216224:14110/17:00098445

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1097/j.pain.0000000000001034

UT WoS

000419133700009

Keywords in English

diabetic neuropathy

Abstract

V originále

Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects. This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with nonpainful (n = 74) and painful (n = 158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores. All parameters were analyzed with regard to the presence and severity of neuropathic pain. Neuropathic pain was positively correlated with the severity of neuropathy and thermal hyposensitivity (P < 0.001). A minority of patients with painful DSPN (14.6%) had a sensory profile, indicating thermal hypersensitivity that was associated with less severe neuropathy. Neuropathic pain was further linked to female sex and higher cognitive appraisal of pain as assessed by the pain catastrophizing scale (P < 0.001), while parameters related to diabetes showed no influence on neuropathic pain with the exception of laboratory signs of nephropathy. This study confirms the value of comprehensive DSPN phenotyping and underlines the importance of the severity of neuropathy for the presence of pain. Different sensory phenotypes might be useful for stratification of patients with painful DSPN for analgesic treatment and drug trials.

Citovat

RAPUTOVÁ, Jana, Iva ŠROTOVÁ, Eva VLČKOVÁ, Claudia SOMMER, Nurcan ÜCEYLER, Frank BIRKLEIN, Heike L. RITTNER, Cora REBHORN, Blanka ADAMOVÁ, Ivana KOVAĽOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Lucas FORER, Jana BĚLOBRÁDKOVÁ, Jindřich OLŠOVSKÝ, Pavel WEBER, Ladislav DUŠEK, Jiří JARKOVSKÝ and Josef BEDNAŘÍK. Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. Pain. Philadelphia: Lippincott Williams & Wilkins, 2017, vol. 158, No 12, p. 2340-2353. ISSN 0304-3959. Available from: https://dx.doi.org/10.1097/j.pain.0000000000001034.

@article{1396372,
   author = {Raputová, Jana and Šrotová, Iva and Vlčková, Eva and Sommer, Claudia and Üceyler, Nurcan and Birklein, Frank and Rittner, Heike L. and Rebhorn, Cora and Adamová, Blanka and Kovaľová, Ivana and Králíčková Nekvapilová, Eva and Forer, Lucas and Bělobrádková, Jana and Olšovský, Jindřich and Weber, Pavel and Dušek, Ladislav and Jarkovský, Jiří and Bednařík, Josef},
   article_location = {Philadelphia},
   article_number = {12},
   doi = {http://dx.doi.org/10.1097/j.pain.0000000000001034},
   keywords = {diabetic neuropathy},
   language = {eng},
   issn = {0304-3959},
   journal = {Pain},
   title = {Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study},
   volume = {158},
   year = {2017}
}

TY  - JOUR
ID  - 1396372
AU  - Raputová, Jana - Šrotová, Iva - Vlčková, Eva - Sommer, Claudia - Üceyler, Nurcan - Birklein, Frank - Rittner, Heike L. - Rebhorn, Cora - Adamová, Blanka - Kovaľová, Ivana - Králíčková Nekvapilová, Eva - Forer, Lucas - Bělobrádková, Jana - Olšovský, Jindřich - Weber, Pavel - Dušek, Ladislav - Jarkovský, Jiří - Bednařík, Josef
PY  - 2017
TI  - Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study
JF  - Pain
VL  - 158
IS  - 12
SP  - 2340-2353
EP  - 2340-2353
PB  - Lippincott Williams & Wilkins
SN  - 03043959
KW  - diabetic neuropathy
N2  - Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects. This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with nonpainful (n = 74) and painful (n = 158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores. All parameters were analyzed with regard to the presence and severity of neuropathic pain. Neuropathic pain was positively correlated with the severity of neuropathy and thermal hyposensitivity (P < 0.001). A minority of patients with painful DSPN (14.6%) had a sensory profile, indicating thermal hypersensitivity that was associated with less severe neuropathy. Neuropathic pain was further linked to female sex and higher cognitive appraisal of pain as assessed by the pain catastrophizing scale (P < 0.001), while parameters related to diabetes showed no influence on neuropathic pain with the exception of laboratory signs of nephropathy. This study confirms the value of comprehensive DSPN phenotyping and underlines the importance of the severity of neuropathy for the presence of pain. Different sensory phenotypes might be useful for stratification of patients with painful DSPN for analgesic treatment and drug trials.
ER  -

RAPUTOVÁ, Jana, Iva ŠROTOVÁ, Eva VLČKOVÁ, Claudia SOMMER, Nurcan ÜCEYLER, Frank BIRKLEIN, Heike L. RITTNER, Cora REBHORN, Blanka ADAMOVÁ, Ivana KOVAĽOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Lucas FORER, Jana BĚLOBRÁDKOVÁ, Jindřich OLŠOVSKÝ, Pavel WEBER, Ladislav DUŠEK, Jiří JARKOVSKÝ and Josef BEDNAŘÍK. Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. \textit{Pain}. Philadelphia: Lippincott Williams \&{} Wilkins, 2017, vol.~158, No~12, p.~2340-2353. ISSN~0304-3959. Available from: https://dx.doi.org/10.1097/j.pain.0000000000001034.

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