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@article{1396372,
author = {Raputová, Jana and Šrotová, Iva and Vlčková, Eva and Sommer, Claudia and Üceyler, Nurcan and Birklein, Frank and Rittner, Heike L. and Rebhorn, Cora and Adamová, Blanka and Kovaľová, Ivana and Králíčková Nekvapilová, Eva and Forer, Lucas and Bělobrádková, Jana and Olšovský, Jindřich and Weber, Pavel and Dušek, Ladislav and Jarkovský, Jiří and Bednařík, Josef},
article_location = {Philadelphia},
article_number = {12},
doi = {http://dx.doi.org/10.1097/j.pain.0000000000001034},
keywords = {diabetic neuropathy},
language = {eng},
issn = {0304-3959},
journal = {Pain},
title = {Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study},
volume = {158},
year = {2017}
}
TY - JOUR
ID - 1396372
AU - Raputová, Jana - Šrotová, Iva - Vlčková, Eva - Sommer, Claudia - Üceyler, Nurcan - Birklein, Frank - Rittner, Heike L. - Rebhorn, Cora - Adamová, Blanka - Kovaľová, Ivana - Králíčková Nekvapilová, Eva - Forer, Lucas - Bělobrádková, Jana - Olšovský, Jindřich - Weber, Pavel - Dušek, Ladislav - Jarkovský, Jiří - Bednařík, Josef
PY - 2017
TI - Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study
JF - Pain
VL - 158
IS - 12
SP - 2340-2353
EP - 2340-2353
PB - Lippincott Williams & Wilkins
SN - 03043959
KW - diabetic neuropathy
N2 - Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects. This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with nonpainful (n = 74) and painful (n = 158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores. All parameters were analyzed with regard to the presence and severity of neuropathic pain. Neuropathic pain was positively correlated with the severity of neuropathy and thermal hyposensitivity (P < 0.001). A minority of patients with painful DSPN (14.6%) had a sensory profile, indicating thermal hypersensitivity that was associated with less severe neuropathy. Neuropathic pain was further linked to female sex and higher cognitive appraisal of pain as assessed by the pain catastrophizing scale (P < 0.001), while parameters related to diabetes showed no influence on neuropathic pain with the exception of laboratory signs of nephropathy. This study confirms the value of comprehensive DSPN phenotyping and underlines the importance of the severity of neuropathy for the presence of pain. Different sensory phenotypes might be useful for stratification of patients with painful DSPN for analgesic treatment and drug trials.
ER -
RAPUTOVÁ, Jana, Iva ŠROTOVÁ, Eva VLČKOVÁ, Claudia SOMMER, Nurcan ÜCEYLER, Frank BIRKLEIN, Heike L. RITTNER, Cora REBHORN, Blanka ADAMOVÁ, Ivana KOVAĽOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Lucas FORER, Jana BĚLOBRÁDKOVÁ, Jindřich OLŠOVSKÝ, Pavel WEBER, Ladislav DUŠEK, Jiří JARKOVSKÝ and Josef BEDNAŘÍK. Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. \textit{Pain}. Philadelphia: Lippincott Williams \&{} Wilkins, vol.~158, No~12, p.~2340-2353. ISSN~0304-3959. doi:10.1097/j.pain.0000000000001034. 2017.
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