Detailed Information on Publication Record
2017
Changes in connectivity of the posterior default network node during visual processing in mild cognitive impairment: staged decline between normal aging and Alzheimer’s disease
KRAJČOVIČOVÁ, Lenka, Marek BARTOŇ, Nela NĚMCOVÁ ELFMARKOVÁ, Michal MIKL, Radek MAREČEK et. al.Basic information
Original name
Changes in connectivity of the posterior default network node during visual processing in mild cognitive impairment: staged decline between normal aging and Alzheimer’s disease
Authors
KRAJČOVIČOVÁ, Lenka (703 Slovakia, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Nela NĚMCOVÁ ELFMARKOVÁ (203 Czech Republic, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Neural Transmission, Wien, Springer, 2017, 0300-9564
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Austria
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.779
RIV identification code
RIV/00216224:14110/17:00098496
Organization unit
Faculty of Medicine
UT WoS
000415365300009
Keywords in English
Dementia; fMRI; Posterior cingulate; Precuneus ;Psychophysiological interactions; Visual pathways
Tags
International impact, Reviewed
Změněno: 13/3/2018 19:39, Soňa Böhmová
Abstract
V originále
Visual processing difficulties are often present in Alzheimer’s disease (AD), even in its pre-dementia phase (i.e. in mild cognitive impairment, MCI). The default mode network (DMN) modulates the brain connectivity depending on the specific cognitive demand, including visual processes. The aim of the present study was to analyze specific changes in connectivity of the posterior DMN node (i.e. the posterior cingulate cortex and precuneus, PCC/P) associated with visual processing in 17 MCI patients and 15 AD patients as compared to 18 healthy controls (HC) using functional magnetic resonance imaging. We used psychophysiological interaction (PPI) analysis to detect specific alterations in PCC connectivity associated with visual processing while controlling for brain atrophy. In the HC group, we observed physiological changes in PCC connectivity in ventral visual stream areas and with PCC/P during the visual task, reflecting the successful involvement of these regions in visual processing. In the MCI group, the PCC connectivity changes were disturbed and remained significant only with the anterior precuneus. In between-group comparison, we observed significant PPI effects in the right superior temporal gyrus in both MCI and AD as compared to HC. This change in connectivity may reflect ineffective “compensatory” mechanism present in the early pre-dementia stages of AD or abnormal modulation of brain connectivity due to the disease pathology. With the disease progression, these changes become more evident but less efficient in terms of compensation. This approach can separate the MCI from HC with 77% sensitivity and 89% specificity.
Links
| LM2015062, research and development project |
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| LQ1601, research and development project |
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