VOLNÝ, Ondřej, Mária JUSTANOVÁ, Petra CIMFLOVÁ, Linda MACHOVÁ, Ivana SVOBODOVÁ, Jan MUŽÍK and Martin BAREŠ. 24-Hour Alberta Stroke Program Early CT Score Assessment in Post-Stroke Spasticity Development in Patients with a First Documented Anterior Circulation Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases. Amsterdam: Elsevier Science BV., vol. 27, No 1, p. 240-245. ISSN 1052-3057. doi:10.1016/j.jstrokecerebrovasdis.2017.08.033. 2018.
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Basic information
Original name 24-Hour Alberta Stroke Program Early CT Score Assessment in Post-Stroke Spasticity Development in Patients with a First Documented Anterior Circulation Ischemic Stroke
Authors VOLNÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), Mária JUSTANOVÁ (203 Czech Republic, belonging to the institution), Petra CIMFLOVÁ (203 Czech Republic, belonging to the institution), Linda MACHOVÁ (203 Czech Republic), Ivana SVOBODOVÁ (203 Czech Republic, belonging to the institution), Jan MUŽÍK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution).
Edition Journal of Stroke and Cerebrovascular Diseases, Amsterdam, Elsevier Science BV. 2018, 1052-3057.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.646
RIV identification code RIV/00216224:14110/18:00102114
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.033
UT WoS 000419584400033
Keywords in English Middle cerebral artery territory; Modified; Ashworth scale; Post-stroke spasticity; Stroke
Tags 14110119, 14110127, 14119612, EL OK, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 13/9/2021 15:01.
Abstract
Background: Neuroanatomic substrates responsible for development of post-stroke spasticity are still poorly understood. The study is focused on identification of brain regions within the territory of the middle cerebral artery associated with spasticity development. Methods: This is a single-center prospective cohort study of first documented anterior circulation ischemic strokes with a neurologic deficit lasting >7 days (from March 2014 to September 2016, all patients are involved in a registry). Ischemic cerebral lesions within the territory of middle cerebral artery were evaluated using the Alberta Stroke Program Early CT Score (ASPECTS) on control 24-hour computed tomography or magnetic resonance imaging. Spasticity was assessed with modified Ashworth scale. Results: Seventy-six patients (mean age 72 years, 45% females; 30% treated with IV tissue plasminogen activator, 6.5% mechanical thrombectomy) fulfilled the study inclusion criteria. Forty-nine (64%) developed early elbow or wrist flexor spasticity defined as modified Ashworth scale >1 (at day 7-10), in 44 (58%) the spasticity remained present at 6 months. There were no differences between the patients who developed spasticity and those who did not when comparing admission stroke severity (National Institutes of Health Stroke Scale 5 [interquartile range (IQR) 4-8] versus 6 [IQR 4-10]) and vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, coronary artery disease). Nor was there a difference in 24-hour ASPECTS score (9 [IQR 8-10] versus 9 [IQR 7-10]). No differences were found between the groups with and without the early upper limb flexor spasticity of particular regions (M1, M2, M3, M4, M5, M6, lentiform, insula, caudate, internal capsule) and precentral-postcentral gyrus, premotor cortex, supplementary motor area, posterior limb of internal capsule, and thalamus were compared. Conclusions: We did not find any middle cerebral artery territory associated with post-stroke spasticity development by detailed evaluation of ASPECTS.
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