| ĎURIŠ, Kamil, Jolana LIPKOVÁ and Michal JURAJDA. Cholinergic Anti-inflammatory Pathway and Stroke. Current Drug Delivery. Sharjah: Bentham Science Publishers, 2017, vol. 14, No 4, p. 449-457. ISSN 1567-2018. Available from: https://dx.doi.org/10.2174/1567201814666170201150015. |
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@article{1397094,
author = {Ďuriš, Kamil and Lipková, Jolana and Jurajda, Michal},
article_location = {Sharjah},
article_number = {4},
doi = {http://dx.doi.org/10.2174/1567201814666170201150015},
keywords = {Cerebral ischemia; cholinergic anti-inflammatory pathway; inflammation; intracerebral hemorrhage; stroke; subarachnoid hemorrhage; Vagus nerve stimulation; alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR)},
language = {eng},
issn = {1567-2018},
journal = {Current Drug Delivery},
title = {Cholinergic Anti-inflammatory Pathway and Stroke},
volume = {14},
year = {2017}
}
TY - JOUR
ID - 1397094
AU - Ďuriš, Kamil - Lipková, Jolana - Jurajda, Michal
PY - 2017
TI - Cholinergic Anti-inflammatory Pathway and Stroke
JF - Current Drug Delivery
VL - 14
IS - 4
SP - 449-457
EP - 449-457
PB - Bentham Science Publishers
SN - 15672018
KW - Cerebral ischemia
KW - cholinergic anti-inflammatory pathway
KW - inflammation
KW - intracerebral hemorrhage
KW - stroke
KW - subarachnoid hemorrhage
KW - Vagus nerve stimulation
KW - alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR)
N2 - Background: Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Methods: Research articles related to cholinergic anti-inflammatory pathway (CHAIP) and stroke were reviewed. The first part of review describes the basic characteristics of inflammatory response after stroke, main components and function of CHAIP. The second part reviews studies focused on CHAIP as a therapeutic target for ischemic and hemorrhagic stroke. Both pharmacological stimulation of alpha 7 nAChR and vagus nerve stimulation after stroke are reviewed. Results: Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) are the main components of CHAIP. Conclusion: Targeting cholinergic anti-inflammatory pathway is a promising way of immunomodulation which attenuates inflammation in a complex manner without causing immunosuppression.
ER -
ĎURIŠ, Kamil, Jolana LIPKOVÁ and Michal JURAJDA. Cholinergic Anti-inflammatory Pathway and Stroke. \textit{Current Drug Delivery}. Sharjah: Bentham Science Publishers, 2017, vol.~14, No~4, p.~449-457. ISSN~1567-2018. Available from: https://dx.doi.org/10.2174/1567201814666170201150015.
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