JIČÍNSKÁ, Hana, P. VLASIN, M. JICINSKY, I. GROCHOVA, V. TOMEK, J. VOLAUFOVA, J. SKOVRANEK and J. MAREK. Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods. Circulation. Philadelphia: Lippincott Williams Wilkins, 2017, vol. 135, No 11, p. 1045-1055. ISSN 0009-7322. Available from: https://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864.
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Basic information
Original name Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods
Authors JIČÍNSKÁ, Hana (203 Czech Republic, guarantor, belonging to the institution), P. VLASIN (203 Czech Republic), M. JICINSKY (203 Czech Republic), I. GROCHOVA (203 Czech Republic), V. TOMEK (203 Czech Republic), J. VOLAUFOVA (840 United States of America), J. SKOVRANEK (203 Czech Republic) and J. MAREK (203 Czech Republic).
Edition Circulation, Philadelphia, Lippincott Williams Wilkins, 2017, 0009-7322.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 18.881
RIV identification code RIV/00216224:14110/17:00098539
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864
UT WoS 000396215400012
Keywords in English congenital heart defects; echocardiography; epidemiology; first-trimester screening; prenatal cardiology
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 21/3/2018 16:14.
Abstract
BACKGROUND: The study analyzed the impact of first-trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and on the outcome of fetuses and children born alive with a CHD. METHODS: The spectrum of CHDs, associated comorbidities, and outcome of fetuses, either diagnosed with a CHD in the first trimester (Group I, 127 fetuses) or only in the second-trimester screening (Group II, 344 fetuses), were analyzed retrospectively between 2007 and 2013. Second-trimester fetuses diagnosed with a CHD between 2007 and 2013 were also compared with Group III (532 fetuses diagnosed with a CHD in the second trimester from 1996 to 2001, the period before first-trimester screening was introduced). RESULTS: The spectrum of CHDs diagnosed in the first and second trimesters in the same time period differed significantly, with a greater number of comorbidities (P< 0.0001), CHDs with univentricular outcome (P< 0.0001), intrauterine deaths (P= 0.01), and terminations of pregnancy (P< 0.0001) in Group I compared with Group II. In Group III, significantly more cases of CHDs with univentricular outcome (P< 0.0001), intrauterine demise (P= 0.036), and early termination (P< 0.0001) were identified compared with fetuses diagnosed with CHDs in the second trimester between 2007 and 2013. The spectrum of CHDs seen in the second-trimester groups differed after first-trimester screening was implemented. CONCLUSIONS: First-trimester screening had a significant impact on the spectrum of CHDs and the outcomes of pregnancies with CHDs diagnosed in the second trimester. Early detection of severe forms of CHDs and significant comorbidities resulted in an increased pregnancy termination rate in the first trimester.
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