Does First-Trimester Screening Modify the Natural History of
Congenital Heart Disease? Analysis of Outcome of Regional
Cardiac Screening at 2 Different Time Periods

J 2017

Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods

JIČÍNSKÁ, Hana, P. VLASIN, M. JICINSKY, I. GROCHOVA, V. TOMEK et. al.

Basic information

Original name

Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods

Authors

JIČÍNSKÁ, Hana (203 Czech Republic, guarantor, belonging to the institution), P. VLASIN (203 Czech Republic), M. JICINSKY (203 Czech Republic), I. GROCHOVA (203 Czech Republic), V. TOMEK (203 Czech Republic), J. VOLAUFOVA (840 United States of America), J. SKOVRANEK (203 Czech Republic) and J. MAREK (203 Czech Republic)

Edition

Circulation, Philadelphia, Lippincott Williams Wilkins, 2017, 0009-7322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 18.881

RIV identification code

RIV/00216224:14110/17:00098539

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864

UT WoS

000396215400012

Keywords in English

congenital heart defects; echocardiography; epidemiology; first-trimester screening; prenatal cardiology

Abstract

V originále

BACKGROUND: The study analyzed the impact of first-trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and on the outcome of fetuses and children born alive with a CHD. METHODS: The spectrum of CHDs, associated comorbidities, and outcome of fetuses, either diagnosed with a CHD in the first trimester (Group I, 127 fetuses) or only in the second-trimester screening (Group II, 344 fetuses), were analyzed retrospectively between 2007 and 2013. Second-trimester fetuses diagnosed with a CHD between 2007 and 2013 were also compared with Group III (532 fetuses diagnosed with a CHD in the second trimester from 1996 to 2001, the period before first-trimester screening was introduced). RESULTS: The spectrum of CHDs diagnosed in the first and second trimesters in the same time period differed significantly, with a greater number of comorbidities (P< 0.0001), CHDs with univentricular outcome (P< 0.0001), intrauterine deaths (P= 0.01), and terminations of pregnancy (P< 0.0001) in Group I compared with Group II. In Group III, significantly more cases of CHDs with univentricular outcome (P< 0.0001), intrauterine demise (P= 0.036), and early termination (P< 0.0001) were identified compared with fetuses diagnosed with CHDs in the second trimester between 2007 and 2013. The spectrum of CHDs seen in the second-trimester groups differed after first-trimester screening was implemented. CONCLUSIONS: First-trimester screening had a significant impact on the spectrum of CHDs and the outcomes of pregnancies with CHDs diagnosed in the second trimester. Early detection of severe forms of CHDs and significant comorbidities resulted in an increased pregnancy termination rate in the first trimester.

Citovat

JIČÍNSKÁ, Hana, P. VLASIN, M. JICINSKY, I. GROCHOVA, V. TOMEK, J. VOLAUFOVA, J. SKOVRANEK and J. MAREK. Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods. Circulation. Philadelphia: Lippincott Williams Wilkins, 2017, vol. 135, No 11, p. 1045-1055. ISSN 0009-7322. Available from: https://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864.

@article{1397191,
   author = {Jičínská, Hana and Vlasin, P. and Jicinsky, M. and Grochova, I. and Tomek, V. and Volaufova, J. and Skovranek, J. and Marek, J.},
   article_location = {Philadelphia},
   article_number = {11},
   doi = {http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864},
   keywords = {congenital heart defects; echocardiography; epidemiology; first-trimester screening; prenatal cardiology},
   language = {eng},
   issn = {0009-7322},
   journal = {Circulation},
   title = {Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods},
   volume = {135},
   year = {2017}
}

TY  - JOUR
ID  - 1397191
AU  - Jičínská, Hana - Vlasin, P. - Jicinsky, M. - Grochova, I. - Tomek, V. - Volaufova, J. - Skovranek, J. - Marek, J.
PY  - 2017
TI  - Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods
JF  - Circulation
VL  - 135
IS  - 11
SP  - 1045-1055
EP  - 1045-1055
PB  - Lippincott Williams Wilkins
SN  - 00097322
KW  - congenital heart defects
KW  - echocardiography
KW  - epidemiology
KW  - first-trimester screening
KW  - prenatal cardiology
N2  - BACKGROUND: The study analyzed the impact of first-trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and on the outcome of fetuses and children born alive with a CHD. METHODS: The spectrum of CHDs, associated comorbidities, and outcome of fetuses, either diagnosed with a CHD in the first trimester (Group I, 127 fetuses) or only in the second-trimester screening (Group II, 344 fetuses), were analyzed retrospectively between 2007 and 2013. Second-trimester fetuses diagnosed with a CHD between 2007 and 2013 were also compared with Group III (532 fetuses diagnosed with a CHD in the second trimester from 1996 to 2001, the period before first-trimester screening was introduced). RESULTS: The spectrum of CHDs diagnosed in the first and second trimesters in the same time period differed significantly, with a greater number of comorbidities (P< 0.0001), CHDs with univentricular outcome (P< 0.0001), intrauterine deaths (P= 0.01), and terminations of pregnancy (P< 0.0001) in Group I compared with Group II. In Group III, significantly more cases of CHDs with univentricular outcome (P< 0.0001), intrauterine demise (P= 0.036), and early termination (P< 0.0001) were identified compared with fetuses diagnosed with CHDs in the second trimester between 2007 and 2013. The spectrum of CHDs seen in the second-trimester groups differed after first-trimester screening was implemented. CONCLUSIONS: First-trimester screening had a significant impact on the spectrum of CHDs and the outcomes of pregnancies with CHDs diagnosed in the second trimester. Early detection of severe forms of CHDs and significant comorbidities resulted in an increased pregnancy termination rate in the first trimester.
ER  -

JIČÍNSKÁ, Hana, P. VLASIN, M. JICINSKY, I. GROCHOVA, V. TOMEK, J. VOLAUFOVA, J. SKOVRANEK and J. MAREK. Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods. \textit{Circulation}. Philadelphia: Lippincott Williams Wilkins, 2017, vol.~135, No~11, p.~1045-1055. ISSN~0009-7322. Available from: https://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864.

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