Poly(I:C) model of schizophrenia in rats induces sex-dependent
functional brain changes detected by MRI that are not reversed
by aripiprazole treatment

J 2018

Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment

DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRATKA, Kateřina HORSKÁ, Regina DEMLOVÁ et. al.

Basic information

Original name

Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment

Name in Czech

Poly(I:C) model schizofrenie u potkana vyvolává funkční MRI změny v mozku v závislosti na pohlaví, které nejsou zvráceny podáváním aripiprazolu

Authors

DRAŽANOVÁ, Eva (203 Czech Republic, belonging to the institution), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution), Lucie KRATKA (203 Czech Republic), Kateřina HORSKÁ (203 Czech Republic), Regina DEMLOVÁ (203 Czech Republic, belonging to the institution), Zenon STARČUK (203 Czech Republic) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution)

Edition

Brain Research Bulletin, Oxford, Pergamon-Elsevier Science LTD, 2018, 0361-9230

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.103

RIV identification code

RIV/00216224:14110/18:00102121

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.brainresbull.2017.11.008

UT WoS

000427344300016

Keywords in English

aripiprazole; Arterial Spin Labelling; Wistar rats; schizophrenia; sex; MRI

Abstract

V originále

ackground and purpose: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. Methods: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical antipsychotic acting as a partial agonist on dopaminergic receptors. Results: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. Conclusion: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.

Links

LM2015062, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

LM2015090, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1063/2016, interní kód MU

Name: Experimentální a translační farmakologický výzkum a vývoj

Investor: Masaryk University, Category A

MUNI/A/1132/2017, interní kód MU

Name: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masaryk University, Category A

Citovat

DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRATKA, Kateřina HORSKÁ, Regina DEMLOVÁ, Zenon STARČUK and Tomáš KAŠPÁREK. Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment. Brain Research Bulletin. Oxford: Pergamon-Elsevier Science LTD, 2018, vol. 137, March 2018, p. 146-155. ISSN 0361-9230. Available from: https://dx.doi.org/10.1016/j.brainresbull.2017.11.008.

@article{1397254,
   author = {Dražanová, Eva and Rudá, Jana and Kratka, Lucie and Horská, Kateřina and Demlová, Regina and Starčuk, Zenon and Kašpárek, Tomáš},
   article_location = {Oxford},
   article_number = {March 2018},
   doi = {http://dx.doi.org/10.1016/j.brainresbull.2017.11.008},
   keywords = {aripiprazole; Arterial Spin Labelling; Wistar rats; schizophrenia; sex; MRI},
   language = {eng},
   issn = {0361-9230},
   journal = {Brain Research Bulletin},
   title = {Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment},
   url = {http://www.sciencedirect.com/science/article/pii/S0361923017305828?via%3Dihub},
   volume = {137},
   year = {2018}
}

TY  - JOUR
ID  - 1397254
AU  - Dražanová, Eva - Rudá, Jana - Kratka, Lucie - Horská, Kateřina - Demlová, Regina - Starčuk, Zenon - Kašpárek, Tomáš
PY  - 2018
TI  - Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment
JF  - Brain Research Bulletin
VL  - 137
IS  - March 2018
SP  - 146-155
EP  - 146-155
PB  - Pergamon-Elsevier Science LTD
SN  - 03619230
KW  - aripiprazole
KW  - Arterial Spin Labelling
KW  - Wistar rats
KW  - schizophrenia
KW  - sex
KW  - MRI
UR  - http://www.sciencedirect.com/science/article/pii/S0361923017305828?via%3Dihub
L2  - http://www.sciencedirect.com/science/article/pii/S0361923017305828?via%3Dihub
N2  - ackground and purpose: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. Methods: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical antipsychotic acting as a partial agonist on dopaminergic receptors. Results: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. Conclusion: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.
ER  -

DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRATKA, Kateřina HORSKÁ, Regina DEMLOVÁ, Zenon STARČUK and Tomáš KAŠPÁREK. Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment. \textit{Brain Research Bulletin}. Oxford: Pergamon-Elsevier Science LTD, 2018, vol.~137, March 2018, p.~146-155. ISSN~0361-9230. Available from: https://dx.doi.org/10.1016/j.brainresbull.2017.11.008.

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