The burden and epidemiology of community-acquired central
nervous system infections: a multinational study

J 2017

The burden and epidemiology of community-acquired central nervous system infections: a multinational study

ERDEM, Hakan, A. INAN, E. GUVEN, S. HARGREAVES, L. LARSEN et. al.

Basic information

Original name

The burden and epidemiology of community-acquired central nervous system infections: a multinational study

Authors

ERDEM, Hakan (792 Turkey), A. INAN (792 Turkey), E. GUVEN (792 Turkey), S. HARGREAVES (826 United Kingdom of Great Britain and Northern Ireland), L. LARSEN (208 Denmark), G. SHEHATA (818 Egypt), Eva PERNICOVÁ (203 Czech Republic), E. KHAN (586 Pakistan), Lenka BAŠTÁKOVÁ (703 Slovakia, guarantor, belonging to the institution), S. NAMANI (95 Republic of Kosovo), A. HARXHI (8 Albania), T. ROGANOVIC (70 Bosnia and Herzegovina), B. LAKATOS (348 Hungary), S. UYSAL (792 Turkey), O. R. SIPAHI (792 Turkey), A. CRISAN (642 Romania), E. MIFTODE (642 Romania), Roman STEBEL (203 Czech Republic, belonging to the institution), B. JEGOROVIC (688 Serbia), Z. FEHER (348 Hungary), C. JEKKEL (348 Hungary), N. PANDAK (191 Croatia), A. MORAVVEJI (364 Islamic Republic of Iran), H. YILMAZ (792 Turkey), A. KHALIFA (760 Syrian Arab Republic), U. MUSABAK (792 Turkey), S. YILMAZ (792 Turkey), A. JOUHAR (760 Syrian Arab Republic), N. OZTOPRAK (792 Turkey), X. ARGEMI (250 France), M. BALDEYROU (250 France), G. BELLAUD (250 France), R. V. MOROTI (642 Romania), R. HASBUN (840 United States of America), L. SALAZAR (840 United States of America), R. TEKIN (792 Turkey), A. CANESTRI (250 France), L. CALKIC (70 Bosnia and Herzegovina), L. PRATICO (380 Italy), F. YILMAZ-KARADAG (792 Turkey), L. SANTOS (620 Portugal), A. PINTO (620 Portugal), F. KAPTAN (792 Turkey), P. BOSSI (250 France), J. ARON (250 France), A. DUISSENOVA (398 Kazakhstan), G. SHOPAYEVA (398 Kazakhstan), B. UTAGANOV (398 Kazakhstan), S. GRGIC (70 Bosnia and Herzegovina), G. ERSOZ (792 Turkey), A. K. L. WU (156 China), K. C. LUNG (156 China), A. BRUZSA (348 Hungary), L. B. RADIC (191 Croatia), H. KAHRAMAN (792 Turkey), M. MOMEN-HERAVI (364 Islamic Republic of Iran), S. KULZHANOVA (398 Kazakhstan), F. RIGO (380 Italy), M. KONKAYEVA (398 Kazakhstan), Z. SMAGULOVA (398 Kazakhstan), T. TANG (156 China), P. CHAN (156 China), S. AHMETAGIC (70 Bosnia and Herzegovina), H. POROBIC-JAHIC (70 Bosnia and Herzegovina), F. MORADI (364 Islamic Republic of Iran), S. KAYA (792 Turkey), Y. CAG (792 Turkey), A. BOHR (208 Denmark), C. ARTUK (792 Turkey), I. CELIK (792 Turkey), M. AMSILLI (250 France), H. C. GUL (792 Turkey), A. CASCIO (380 Italy), M. LANZAFAME (380 Italy) and M. NASSAR (682 Saudi Arabia)

Edition

European Journal of Clinical Microbiology & Infectious Diseases, New York, Springer, 2017, 0934-9723

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.537

RIV identification code

RIV/00216224:14110/17:00098556

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10096-017-2973-0

UT WoS

000407582200010

Keywords in English

Central nervous system infections; Epidemiology; Streptococcus pneumoniae; Neurosyphilis; Neuroborreliosis; CNS tuberculosis

Abstract

V originále

Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.

Citovat

ERDEM, Hakan, A. INAN, E. GUVEN, S. HARGREAVES, L. LARSEN, G. SHEHATA, Eva PERNICOVÁ, E. KHAN, Lenka BAŠTÁKOVÁ, S. NAMANI, A. HARXHI, T. ROGANOVIC, B. LAKATOS, S. UYSAL, O. R. SIPAHI, A. CRISAN, E. MIFTODE, Roman STEBEL, B. JEGOROVIC, Z. FEHER, C. JEKKEL, N. PANDAK, A. MORAVVEJI, H. YILMAZ, A. KHALIFA, U. MUSABAK, S. YILMAZ, A. JOUHAR, N. OZTOPRAK, X. ARGEMI, M. BALDEYROU, G. BELLAUD, R. V. MOROTI, R. HASBUN, L. SALAZAR, R. TEKIN, A. CANESTRI, L. CALKIC, L. PRATICO, F. YILMAZ-KARADAG, L. SANTOS, A. PINTO, F. KAPTAN, P. BOSSI, J. ARON, A. DUISSENOVA, G. SHOPAYEVA, B. UTAGANOV, S. GRGIC, G. ERSOZ, A. K. L. WU, K. C. LUNG, A. BRUZSA, L. B. RADIC, H. KAHRAMAN, M. MOMEN-HERAVI, S. KULZHANOVA, F. RIGO, M. KONKAYEVA, Z. SMAGULOVA, T. TANG, P. CHAN, S. AHMETAGIC, H. POROBIC-JAHIC, F. MORADI, S. KAYA, Y. CAG, A. BOHR, C. ARTUK, I. CELIK, M. AMSILLI, H. C. GUL, A. CASCIO, M. LANZAFAME and M. NASSAR. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. European Journal of Clinical Microbiology & Infectious Diseases. New York: Springer, 2017, vol. 36, No 9, p. 1595-1611. ISSN 0934-9723. Available from: https://dx.doi.org/10.1007/s10096-017-2973-0.

@article{1397293,
   author = {Erdem, Hakan and Inan, A. and Guven, E. and Hargreaves, S. and Larsen, L. and Shehata, G. and Pernicová, Eva and Khan, E. and Baštáková, Lenka and Namani, S. and Harxhi, A. and Roganovic, T. and Lakatos, B. and Uysal, S. and Sipahi, O. R. and Crisan, A. and Miftode, E. and Stebel, Roman and Jegorovic, B. and Feher, Z. and Jekkel, C. and Pandak, N. and Moravveji, A. and Yilmaz, H. and Khalifa, A. and Musabak, U. and Yilmaz, S. and Jouhar, A. and Oztoprak, N. and Argemi, X. and Baldeyrou, M. and Bellaud, G. and Moroti, R. V. and Hasbun, R. and Salazar, L. and Tekin, R. and Canestri, A. and Calkic, L. and Pratico, L. and YilmazandKaradag, F. and Santos, L. and Pinto, A. and Kaptan, F. and Bossi, P. and Aron, J. and Duissenova, A. and Shopayeva, G. and Utaganov, B. and Grgic, S. and Ersoz, G. and Wu, A. K. L. and Lung, K. C. and Bruzsa, A. and Radic, L. B. and Kahraman, H. and MomenandHeravi, M. and Kulzhanova, S. and Rigo, F. and Konkayeva, M. and Smagulova, Z. and Tang, T. and Chan, P. and Ahmetagic, S. and PorobicandJahic, H. and Moradi, F. and Kaya, S. and Cag, Y. and Bohr, A. and Artuk, C. and Celik, I. and Amsilli, M. and Gul, H. C. and Cascio, A. and Lanzafame, M. and Nassar, M.},
   article_location = {New York},
   article_number = {9},
   doi = {http://dx.doi.org/10.1007/s10096-017-2973-0},
   keywords = {Central nervous system infections; Epidemiology; Streptococcus pneumoniae; Neurosyphilis; Neuroborreliosis; CNS tuberculosis},
   language = {eng},
   issn = {0934-9723},
   journal = {European Journal of Clinical Microbiology & Infectious Diseases},
   title = {The burden and epidemiology of community-acquired central nervous system infections: a multinational study},
   url = {https://link.springer.com/article/10.1007%2Fs10096-017-2973-0},
   volume = {36},
   year = {2017}
}

TY  - JOUR
ID  - 1397293
AU  - Erdem, Hakan - Inan, A. - Guven, E. - Hargreaves, S. - Larsen, L. - Shehata, G. - Pernicová, Eva - Khan, E. - Baštáková, Lenka - Namani, S. - Harxhi, A. - Roganovic, T. - Lakatos, B. - Uysal, S. - Sipahi, O. R. - Crisan, A. - Miftode, E. - Stebel, Roman - Jegorovic, B. - Feher, Z. - Jekkel, C. - Pandak, N. - Moravveji, A. - Yilmaz, H. - Khalifa, A. - Musabak, U. - Yilmaz, S. - Jouhar, A. - Oztoprak, N. - Argemi, X. - Baldeyrou, M. - Bellaud, G. - Moroti, R. V. - Hasbun, R. - Salazar, L. - Tekin, R. - Canestri, A. - Calkic, L. - Pratico, L. - Yilmaz-Karadag, F. - Santos, L. - Pinto, A. - Kaptan, F. - Bossi, P. - Aron, J. - Duissenova, A. - Shopayeva, G. - Utaganov, B. - Grgic, S. - Ersoz, G. - Wu, A. K. L. - Lung, K. C. - Bruzsa, A. - Radic, L. B. - Kahraman, H. - Momen-Heravi, M. - Kulzhanova, S. - Rigo, F. - Konkayeva, M. - Smagulova, Z. - Tang, T. - Chan, P. - Ahmetagic, S. - Porobic-Jahic, H. - Moradi, F. - Kaya, S. - Cag, Y. - Bohr, A. - Artuk, C. - Celik, I. - Amsilli, M. - Gul, H. C. - Cascio, A. - Lanzafame, M. - Nassar, M.
PY  - 2017
TI  - The burden and epidemiology of community-acquired central nervous system infections: a multinational study
JF  - European Journal of Clinical Microbiology & Infectious Diseases
VL  - 36
IS  - 9
SP  - 1595-1611
EP  - 1595-1611
PB  - Springer
SN  - 09349723
KW  - Central nervous system infections
KW  - Epidemiology
KW  - Streptococcus pneumoniae
KW  - Neurosyphilis
KW  - Neuroborreliosis
KW  - CNS tuberculosis
UR  - https://link.springer.com/article/10.1007%2Fs10096-017-2973-0
L2  - https://link.springer.com/article/10.1007%2Fs10096-017-2973-0
N2  - Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
ER  -

ERDEM, Hakan, A. INAN, E. GUVEN, S. HARGREAVES, L. LARSEN, G. SHEHATA, Eva PERNICOVÁ, E. KHAN, Lenka BAŠTÁKOVÁ, S. NAMANI, A. HARXHI, T. ROGANOVIC, B. LAKATOS, S. UYSAL, O. R. SIPAHI, A. CRISAN, E. MIFTODE, Roman STEBEL, B. JEGOROVIC, Z. FEHER, C. JEKKEL, N. PANDAK, A. MORAVVEJI, H. YILMAZ, A. KHALIFA, U. MUSABAK, S. YILMAZ, A. JOUHAR, N. OZTOPRAK, X. ARGEMI, M. BALDEYROU, G. BELLAUD, R. V. MOROTI, R. HASBUN, L. SALAZAR, R. TEKIN, A. CANESTRI, L. CALKIC, L. PRATICO, F. YILMAZ-KARADAG, L. SANTOS, A. PINTO, F. KAPTAN, P. BOSSI, J. ARON, A. DUISSENOVA, G. SHOPAYEVA, B. UTAGANOV, S. GRGIC, G. ERSOZ, A. K. L. WU, K. C. LUNG, A. BRUZSA, L. B. RADIC, H. KAHRAMAN, M. MOMEN-HERAVI, S. KULZHANOVA, F. RIGO, M. KONKAYEVA, Z. SMAGULOVA, T. TANG, P. CHAN, S. AHMETAGIC, H. POROBIC-JAHIC, F. MORADI, S. KAYA, Y. CAG, A. BOHR, C. ARTUK, I. CELIK, M. AMSILLI, H. C. GUL, A. CASCIO, M. LANZAFAME and M. NASSAR. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. \textit{European Journal of Clinical Microbiology \&{} Infectious Diseases}. New York: Springer, 2017, vol.~36, No~9, p.~1595-1611. ISSN~0934-9723. Available from: https://dx.doi.org/10.1007/s10096-017-2973-0.

Detailed Information on Publication Record