Transcription factor c-Myb inhibits breast cancer lung
metastasis by suppression of tumor cell seeding

J 2018

Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding

KNOPFOVÁ, Lucia, Elisabetta BIGLIERI, Natalya VOLODKO, Michal MASAŘÍK, Markéta HERMANOVÁ et. al.

Basic information

Original name

Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding

Authors

KNOPFOVÁ, Lucia (203 Czech Republic, guarantor, belonging to the institution), Elisabetta BIGLIERI (380 Italy), Natalya VOLODKO (804 Ukraine), Michal MASAŘÍK (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Jesus Francisco GLAUS GARZÓN (756 Switzerland), Monika DÚCKA (703 Slovakia, belonging to the institution), Tereza KUČÍRKOVÁ (203 Czech Republic, belonging to the institution), Karel SOUČEK (203 Czech Republic, belonging to the institution), Jan ŠMARDA (203 Czech Republic, belonging to the institution), Petr BENEŠ (203 Czech Republic, belonging to the institution) and Lubor BORSIG (703 Slovakia)

Edition

Oncogene, London, Nature Publishing Group, 2018, 0950-9232

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.634

RIV identification code

RIV/00216224:14310/18:00100761

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/onc.2017.392

UT WoS

000425905700005

Keywords (in Czech)

Myb; endotel; zánět; Ccl2; metastáza; prsní nádory

Keywords in English

Myb; endothelium; inflammation; Ccl2; metastasis; breast cancer

Abstract

V originále

Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacity exhibited low c-Myb levels. We identified a specific inflammatory signature, including Ccl2 chemokine; that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. Tumor cell-derived Ccl2 expression facilitated lung metastasis and rescued trans-endothelial migration of c-Myb overexpressing cells. Clinical data show that the identified inflammatory signature, together with a MYB expression, predicts lung metastasis relapse in BC patients. These results demonstrate that the c-Myb-regulated transcriptional program in BCs results in a blunted inflammatory response and consequently suppresses lung metastasis.

Links

GJ17-08985Y, research and development project

Name: Prozánětlivá signalizace pod kontrolou proteinu c-Myb v bazálních prsních karcinomech

Investor: Czech Science Foundation

IZ73Z0_152361/1, interní kód MU

Name: c-Myb and Ruk/CIN85 modulate the signaling in breast cancer thereby affecting metastasis (Acronym: c-Myb and Ruk/CIN85 signaling affects metastasis)

Investor: Ostatní - foreign, SCOPES - Scientific Co-operation between Eastern Europe and Switzerland

Citovat

KNOPFOVÁ, Lucia, Elisabetta BIGLIERI, Natalya VOLODKO, Michal MASAŘÍK, Markéta HERMANOVÁ, Jesus Francisco GLAUS GARZÓN, Monika DÚCKA, Tereza KUČÍRKOVÁ, Karel SOUČEK, Jan ŠMARDA, Petr BENEŠ and Lubor BORSIG. Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. Oncogene. London: Nature Publishing Group, 2018, vol. 37, No 8, p. 1020-1030. ISSN 0950-9232. Available from: https://dx.doi.org/10.1038/onc.2017.392.

@article{1398032,
   author = {Knopfová, Lucia and Biglieri, Elisabetta and Volodko, Natalya and Masařík, Michal and Hermanová, Markéta and Glaus Garzón, Jesus Francisco and Dúcka, Monika and Kučírková, Tereza and Souček, Karel and Šmarda, Jan and Beneš, Petr and Borsig, Lubor},
   article_location = {London},
   article_number = {8},
   doi = {http://dx.doi.org/10.1038/onc.2017.392},
   keywords = {Myb; endothelium; inflammation; Ccl2; metastasis; breast cancer},
   language = {eng},
   issn = {0950-9232},
   journal = {Oncogene},
   note = {Rok uplatnění 2018, přenášet do RIV až v roce 2019!},
   title = {Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding},
   url = {http://dx.doi.org/10.1038/onc.2017.392},
   volume = {37},
   year = {2018}
}

TY  - JOUR
ID  - 1398032
AU  - Knopfová, Lucia - Biglieri, Elisabetta - Volodko, Natalya - Masařík, Michal - Hermanová, Markéta - Glaus Garzón, Jesus Francisco - Dúcka, Monika - Kučírková, Tereza - Souček, Karel - Šmarda, Jan - Beneš, Petr - Borsig, Lubor
PY  - 2018
TI  - Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding
JF  - Oncogene
VL  - 37
IS  - 8
SP  - 1020-1030
EP  - 1020-1030
PB  - Nature Publishing Group
SN  - 09509232
N1  - Rok uplatnění 2018, přenášet do RIV až v roce 2019!
KW  - Myb
KW  - endothelium
KW  - inflammation
KW  - Ccl2
KW  - metastasis
KW  - breast cancer
UR  - http://dx.doi.org/10.1038/onc.2017.392
N2  - Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacity exhibited low c-Myb levels. We identified a specific inflammatory signature, including Ccl2 chemokine; that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. Tumor cell-derived Ccl2 expression facilitated lung metastasis and rescued trans-endothelial migration of c-Myb overexpressing cells. Clinical data show that the identified inflammatory signature, together with a MYB expression, predicts lung metastasis relapse in BC patients. These results demonstrate that the c-Myb-regulated transcriptional program in BCs results in a blunted inflammatory response and consequently suppresses lung metastasis.
ER  -

KNOPFOVÁ, Lucia, Elisabetta BIGLIERI, Natalya VOLODKO, Michal MASAŘÍK, Markéta HERMANOVÁ, Jesus Francisco GLAUS GARZÓN, Monika DÚCKA, Tereza KUČÍRKOVÁ, Karel SOUČEK, Jan ŠMARDA, Petr BENEŠ and Lubor BORSIG. Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. \textit{Oncogene}. London: Nature Publishing Group, 2018, vol.~37, No~8, p.~1020-1030. ISSN~0950-9232. Available from: https://dx.doi.org/10.1038/onc.2017.392.

Detailed Information on Publication Record