NESTELBERGER, T., J. BOEDDINGHAUS, P. BADERTSCHER, R. TWERENBOLD, K. WILDI, D. BREITENBUCHER, Z. SABTI, C. PUELACHER, M.R. GIMENEZ, N. KOZHUHAROV, I. STREBEL, L. SAZGARY, D. SCHNEIDER, J. JANN, J. DU FAY DE LAVALLAZ, O. MIRO, F.J. MARTIN-SANCHEZ, B. MORAWIEC, D. KAWECKI, P. MUZYK, D.I. KELLER, N. GEIGY, S. OSSWALD, T. REICHLIN and C. MUELLER. Effect of Definition on Incidence and Prognosis of Type 2 Myocardial Infarction. Online. Journal of The American College of Cardiology. USA: Elsevier Science Inc., 2017, vol. 70, No 13, p. 1558-1568. ISSN 0735-1097. Available from: https://dx.doi.org/10.1016/j.jacc.2017.07.774. [citováno 2024-04-23]
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Basic information
Original name Effect of Definition on Incidence and Prognosis of Type 2 Myocardial Infarction
Authors NESTELBERGER, T., J. BOEDDINGHAUS, P. BADERTSCHER, R. TWERENBOLD, K. WILDI, D. BREITENBUCHER, Z. SABTI, C. PUELACHER, M.R. GIMENEZ, N. KOZHUHAROV, I. STREBEL, L. SAZGARY, D. SCHNEIDER, J. JANN, J. DU FAY DE LAVALLAZ, O. MIRO, F.J. MARTIN-SANCHEZ, B. MORAWIEC, D. KAWECKI, P. MUZYK, D.I. KELLER, N. GEIGY, S. OSSWALD, T. REICHLIN and C. MUELLER
Edition Journal of The American College of Cardiology, USA, Elsevier Science Inc. 2017, 0735-1097.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 16.834
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jacc.2017.07.774
UT WoS 000410985400003
Keywords in English diagnosis; high-sensitivity cardiac troponin; type 2 myocardial infarction
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 5/12/2017 13:14.
Abstract
BACKGROUND Uncertainties regarding the most appropriate definition and treatment of type 2 myocardial infarction (T2MI) due to supply-demand mismatch have contributed to inconsistent adoption in clinical practice. OBJECTIVES This study sought a better understanding of the effect of the definition of T2MI on its incidence, treatment, and event-related mortality, thereby addressing an important unmet clinical need. METHODS The final diagnosis was adjudicated in patients presenting with symptoms suggestive of myocardial infarction by 2 independent cardiologists by 2 methods: 1 method required the presence of coronary artery disease, a common interpretation of the 2007 universal definition (T2MI(2007)); and 1 method did not require coronary artery disease, the 2012 universal definition (T2MI(2012)). RESULTS Overall, 4,015 consecutive patients were adjudicated. The incidence of T2MI based on the T2MI(2007) definition was 2.8% (n = 112). The application of the more liberal T2MI(2012) definition resulted in an increase of T2MI incidence of 6% (n = 240), a relative increase of 114% (128 reclassified patients, defined as T2MI(2012reclassified)). Among T2MI(2007), 6.3% of patients received coronary revascularization, 22% dual-antiplatelet therapy, and 71% high-dose statin therapy versus 0.8%, 1.6%, and 31% among T2MI(2012reclassified) patients, respectively (all p < 0.01). Cardiovascular mortality at 90 days was 0% among T2MI(2012reclassified), which was similar to patients with noncardiac causes of chest discomfort (0.2%), and lower than T2MI(2007) (3.6%) and type 1 myocardial infarction (T1MI) (4.8%) (T2MI(2012reclassified) vs. T2MI(2007) and T1MI: p = 0.03 and 0.01, respectively). CONCLUSIONS T2MI(2012reclassified) has a substantially lower event-related mortality rate compared with T2MI(2007) and T1MI. (Advantageous Predictors of Acute Coronary Syndromes Evaluation [APACE] Study; NCT00470587) (C) 2017 by the American College of Cardiology Foundation.
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