| GAYAT, Etienne, Mattia ARRIGO, Simona LITTNEROVÁ, Naoki SATO, Jiří PAŘENICA, Shiro ISHIHARA, Jindřich ŠPINAR, Christian MULLER, Veli-Pekka HARJOLA, Johan LASSUS, Oscar MIRO, Aldo P. MAGGIONI, Khalid F. ALHABIB, Dong-Ju CHOI, Jin Joo PARK, Yuhui ZHANG, Jian ZHANG, James L., Jr. JANUZZI, Katsuya KAJIMOTO, Alain COHEN-SOLAL and Alexandre MEBAZAA. Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: a propensity-score matched study (Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: A propensity-score matched study). European Journal of heart Failure. Hoboken: Wiley, 2018, vol. 20, No 2, p. 345-354. ISSN 1388-9842. Available from: https://dx.doi.org/10.1002/ejhf.932. |
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@article{1398077,
author = {Gayat, Etienne and Arrigo, Mattia and Littnerová, Simona and Sato, Naoki and Pařenica, Jiří and Ishihara, Shiro and Špinar, Jindřich and Muller, Christian and Harjola, VeliandPekka and Lassus, Johan and Miro, Oscar and Maggioni, Aldo P. and AlHabib, Khalid F. and Choi, DongandJu and Park, Jin Joo and Zhang, Yuhui and Zhang, Jian and Januzzi, James L., Jr. and Kajimoto, Katsuya and CohenandSolal, Alain and Mebazaa, Alexandre},
article_location = {Hoboken},
article_number = {2},
doi = {http://dx.doi.org/10.1002/ejhf.932},
keywords = {Acute heart failure; Prognosis; Oral therapy},
language = {eng},
issn = {1388-9842},
journal = {European Journal of heart Failure},
title = {Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: a propensity-score matched study},
volume = {20},
year = {2018}
}
TY - JOUR
ID - 1398077
AU - Gayat, Etienne - Arrigo, Mattia - Littnerová, Simona - Sato, Naoki - Pařenica, Jiří - Ishihara, Shiro - Špinar, Jindřich - Muller, Christian - Harjola, Veli-Pekka - Lassus, Johan - Miro, Oscar - Maggioni, Aldo P. - AlHabib, Khalid F. - Choi, Dong-Ju - Park, Jin Joo - Zhang, Yuhui - Zhang, Jian - Januzzi, James L., Jr. - Kajimoto, Katsuya - Cohen-Solal, Alain - Mebazaa, Alexandre
PY - 2018
TI - Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: a propensity-score matched study
JF - European Journal of heart Failure
VL - 20
IS - 2
SP - 345-354
EP - 345-354
PB - Wiley
SN - 13889842
KW - Acute heart failure
KW - Prognosis
KW - Oral therapy
N2 - Aims Heart failure oral therapies (HFOTs), including beta-blockers (BB), renin-angiotensin system inhibitors (RASi) and mineralocorticoid receptor antagonists, administered before hospital discharge after acute heart failure (AHF) might improve outcome. However, concerns have been raised because early administration of HFOTs may worsen patient's condition. We hypothesized that HFOTs at hospital discharge might be associated with better post-discharge survival.& para;& para;Methods and results The study population was composed of 19 980 AHF patients from the GREAT registry. The primary and secondary and results outcomes were 90-day and 1-year all-cause mortality, respectively. Survival was estimated with univariate and covariate-adjusted Cox proportional hazards regression models for the whole population and after propensity-score matching. HFOTs at discharge were consistently associated with no excess mortality in the unadjusted and adjusted analyses of the whole and matched cohorts. In the matched cohort, BB and RASi at discharge were associated with lower 90-day mortality risks compared to the respective untreated groups [hazard ratio (HR) 0.56, 95% confidence interval (CI) 0.46-0.69; and HR 0.53, 95% CI 0.42-0.66, respectively]. The favourable associations of BB and RASi at discharge with 90-day mortality were present in many subgroups including patients with reduced or preserved left ventricular ejection fraction and persisted up to 1 year after discharge. The combination of RASi and BB was associated with an even lower risk of death than RASi or BB alone.& para;& para;Conclusions Administration of HFOTs at hospital discharge is associated with better survival of AHF patients.
ER -
GAYAT, Etienne, Mattia ARRIGO, Simona LITTNEROVÁ, Naoki SATO, Jiří PAŘENICA, Shiro ISHIHARA, Jindřich ŠPINAR, Christian MULLER, Veli-Pekka HARJOLA, Johan LASSUS, Oscar MIRO, Aldo P. MAGGIONI, Khalid F. ALHABIB, Dong-Ju CHOI, Jin Joo PARK, Yuhui ZHANG, Jian ZHANG, James L., Jr. JANUZZI, Katsuya KAJIMOTO, Alain COHEN-SOLAL and Alexandre MEBAZAA. Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: a propensity-score matched study (Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: A propensity-score matched study). \textit{European Journal of heart Failure}. Hoboken: Wiley, 2018, vol.~20, No~2, p.~345-354. ISSN~1388-9842. Available from: https://dx.doi.org/10.1002/ejhf.932.
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