Perspectives and challenges of antioxidant therapy for atrial
fibrillation

J 2017

Perspectives and challenges of antioxidant therapy for atrial fibrillation

GASPAROVA, I., P. KUBATKA, R. OPATRILOVA, M. CAPRNDA, S. FILIPOVA et. al.

Basic information

Original name

Perspectives and challenges of antioxidant therapy for atrial fibrillation

Authors

GASPAROVA, I. (703 Slovakia), P. KUBATKA (703 Slovakia), R. OPATRILOVA (203 Czech Republic), M. CAPRNDA (703 Slovakia), S. FILIPOVA (703 Slovakia), L. RODRIGO (724 Spain), L. MALAN (710 South Africa), I. MOZOS (642 Romania), M. RABAJDOVA (703 Slovakia), V. NOSAL (703 Slovakia), N. KOBYLIAK (804 Ukraine), V. VALENTOVA (703 Slovakia), D. PETROVIC (703 Slovakia), M. ADAMEK (616 Poland) and Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution)

Edition

Naunyn-Schmiedebergs Archives of Pharmacology, New York, Springer, 2017, 0028-1298

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.238

RIV identification code

RIV/00216224:14110/17:00098629

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00210-016-1320-9

UT WoS

000391361200001

Keywords in English

Atrial fibrillation; Atrial remodeling; Oxidative stress; Antioxidants; Prevention; Gene therapy

Abstract

V originále

Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.

Citovat

GASPAROVA, I., P. KUBATKA, R. OPATRILOVA, M. CAPRNDA, S. FILIPOVA, L. RODRIGO, L. MALAN, I. MOZOS, M. RABAJDOVA, V. NOSAL, N. KOBYLIAK, V. VALENTOVA, D. PETROVIC, M. ADAMEK and Peter KRUŽLIAK. Perspectives and challenges of antioxidant therapy for atrial fibrillation. Naunyn-Schmiedebergs Archives of Pharmacology. New York: Springer, 2017, vol. 390, No 1, p. 1-14. ISSN 0028-1298. Available from: https://dx.doi.org/10.1007/s00210-016-1320-9.

@article{1398261,
   author = {Gasparova, I. and Kubatka, P. and Opatrilova, R. and Caprnda, M. and Filipova, S. and Rodrigo, L. and Malan, L. and Mozos, I. and Rabajdova, M. and Nosal, V. and Kobyliak, N. and Valentova, V. and Petrovic, D. and Adamek, M. and Kružliak, Peter},
   article_location = {New York},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s00210-016-1320-9},
   keywords = {Atrial fibrillation; Atrial remodeling; Oxidative stress; Antioxidants; Prevention; Gene therapy},
   language = {eng},
   issn = {0028-1298},
   journal = {Naunyn-Schmiedebergs Archives of Pharmacology},
   title = {Perspectives and challenges of antioxidant therapy for atrial fibrillation},
   volume = {390},
   year = {2017}
}

TY  - JOUR
ID  - 1398261
AU  - Gasparova, I. - Kubatka, P. - Opatrilova, R. - Caprnda, M. - Filipova, S. - Rodrigo, L. - Malan, L. - Mozos, I. - Rabajdova, M. - Nosal, V. - Kobyliak, N. - Valentova, V. - Petrovic, D. - Adamek, M. - Kružliak, Peter
PY  - 2017
TI  - Perspectives and challenges of antioxidant therapy for atrial fibrillation
JF  - Naunyn-Schmiedebergs Archives of Pharmacology
VL  - 390
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - Springer
SN  - 00281298
KW  - Atrial fibrillation
KW  - Atrial remodeling
KW  - Oxidative stress
KW  - Antioxidants
KW  - Prevention
KW  - Gene therapy
N2  - Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.
ER  -

GASPAROVA, I., P. KUBATKA, R. OPATRILOVA, M. CAPRNDA, S. FILIPOVA, L. RODRIGO, L. MALAN, I. MOZOS, M. RABAJDOVA, V. NOSAL, N. KOBYLIAK, V. VALENTOVA, D. PETROVIC, M. ADAMEK and Peter KRUŽLIAK. Perspectives and challenges of antioxidant therapy for atrial fibrillation. \textit{Naunyn-Schmiedebergs Archives of Pharmacology}. New York: Springer, 2017, vol.~390, No~1, p.~1-14. ISSN~0028-1298. Available from: https://dx.doi.org/10.1007/s00210-016-1320-9.

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