GASPAROVA, I., P. KUBATKA, R. OPATRILOVA, M. CAPRNDA, S. FILIPOVA, L. RODRIGO, L. MALAN, I. MOZOS, M. RABAJDOVA, V. NOSAL, N. KOBYLIAK, V. VALENTOVA, D. PETROVIC, M. ADAMEK and Peter KRUŽLIAK. Perspectives and challenges of antioxidant therapy for atrial fibrillation. Naunyn-Schmiedebergs Archives of Pharmacology. New York: Springer, vol. 390, No 1, p. 1-14. ISSN 0028-1298. doi:10.1007/s00210-016-1320-9. 2017.
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Basic information
Original name Perspectives and challenges of antioxidant therapy for atrial fibrillation
Authors GASPAROVA, I. (703 Slovakia), P. KUBATKA (703 Slovakia), R. OPATRILOVA (203 Czech Republic), M. CAPRNDA (703 Slovakia), S. FILIPOVA (703 Slovakia), L. RODRIGO (724 Spain), L. MALAN (710 South Africa), I. MOZOS (642 Romania), M. RABAJDOVA (703 Slovakia), V. NOSAL (703 Slovakia), N. KOBYLIAK (804 Ukraine), V. VALENTOVA (703 Slovakia), D. PETROVIC (703 Slovakia), M. ADAMEK (616 Poland) and Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution).
Edition Naunyn-Schmiedebergs Archives of Pharmacology, New York, Springer, 2017, 0028-1298.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.238
RIV identification code RIV/00216224:14110/17:00098629
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s00210-016-1320-9
UT WoS 000391361200001
Keywords in English Atrial fibrillation; Atrial remodeling; Oxidative stress; Antioxidants; Prevention; Gene therapy
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 20/3/2018 13:01.
Abstract
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.
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