| SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA, R. OPATRILOVA, V. VALENTOVA, M. ADAMEK, Peter KRUŽLIAK a M. PODBREGAR. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. Online. Nutrition and cancer : an international journal. Abingdon: Routledge Journals, Taylor & Francis, 2017, roč. 69, č. 2, s. 177-183. ISSN 0163-5581. Dostupné z: https://dx.doi.org/10.1080/01635581.2017.1263751. [citováno 2024-04-23] |
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@article{1398264,
author = {Salamon, S. and Podbregar, E. and Kubatka, P. and Busselberg, D. and Caprnda, M. and Opatrilova, R. and Valentova, V. and Adamek, M. and Kružliak, Peter and Podbregar, M.},
article_location = {Abingdon},
article_number = {2},
doi = {http://dx.doi.org/10.1080/01635581.2017.1263751},
keywords = {Glucose Metabolism},
language = {eng},
issn = {0163-5581},
journal = {Nutrition and cancer : an international journal},
title = {Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect},
volume = {69},
year = {2017}
}
TY - JOUR
ID - 1398264
AU - Salamon, S. - Podbregar, E. - Kubatka, P. - Busselberg, D. - Caprnda, M. - Opatrilova, R. - Valentova, V. - Adamek, M. - Kružliak, Peter - Podbregar, M.
PY - 2017
TI - Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
JF - Nutrition and cancer : an international journal
VL - 69
IS - 2
SP - 177-183
EP - 177-183
PB - Routledge Journals, Taylor & Francis
SN - 01635581
KW - Glucose Metabolism
N2 - The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysiseven in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the -blockers (adrenergic -antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective -blockers have been shown to promote glucose oxidation. Might there be a link?
ER -
SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA, R. OPATRILOVA, V. VALENTOVA, M. ADAMEK, Peter KRUŽLIAK a M. PODBREGAR. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. Online. \textit{Nutrition and cancer : an international journal}. Abingdon: Routledge Journals, Taylor \&{} Francis, 2017, roč.~69, č.~2, s.~177-183. ISSN~0163-5581. Dostupné z: https://dx.doi.org/10.1080/01635581.2017.1263751. [citováno 2024-04-23]
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