Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic
Consequences of the Warburg Effect

J 2017

Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect

SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA et. al.

Basic information

Original name

Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect

Authors

SALAMON, S. (705 Slovenia), E. PODBREGAR (705 Slovenia), P. KUBATKA (703 Slovakia), D. BUSSELBERG (634 Qatar), M. CAPRNDA (703 Slovakia), R. OPATRILOVA (203 Czech Republic), V. VALENTOVA (703 Slovakia), M. ADAMEK (703 Slovakia), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and M. PODBREGAR (705 Slovenia)

Edition

Nutrition and cancer : an international journal, Abingdon, Routledge Journals, Taylor & Francis, 2017, 0163-5581

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.261

RIV identification code

RIV/00216224:14110/17:00098632

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1080/01635581.2017.1263751

UT WoS

000394613600001

Keywords in English

Glucose Metabolism

Abstract

V originále

The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysiseven in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the -blockers (adrenergic -antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective -blockers have been shown to promote glucose oxidation. Might there be a link?

Citovat

SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA, R. OPATRILOVA, V. VALENTOVA, M. ADAMEK, Peter KRUŽLIAK and M. PODBREGAR. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. Nutrition and cancer : an international journal. Abingdon: Routledge Journals, Taylor & Francis, 2017, vol. 69, No 2, p. 177-183. ISSN 0163-5581. Available from: https://dx.doi.org/10.1080/01635581.2017.1263751.

@article{1398264,
   author = {Salamon, S. and Podbregar, E. and Kubatka, P. and Busselberg, D. and Caprnda, M. and Opatrilova, R. and Valentova, V. and Adamek, M. and Kružliak, Peter and Podbregar, M.},
   article_location = {Abingdon},
   article_number = {2},
   doi = {http://dx.doi.org/10.1080/01635581.2017.1263751},
   keywords = {Glucose Metabolism},
   language = {eng},
   issn = {0163-5581},
   journal = {Nutrition and cancer : an international journal},
   title = {Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect},
   volume = {69},
   year = {2017}
}

TY  - JOUR
ID  - 1398264
AU  - Salamon, S. - Podbregar, E. - Kubatka, P. - Busselberg, D. - Caprnda, M. - Opatrilova, R. - Valentova, V. - Adamek, M. - Kružliak, Peter - Podbregar, M.
PY  - 2017
TI  - Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
JF  - Nutrition and cancer : an international journal
VL  - 69
IS  - 2
SP  - 177-183
EP  - 177-183
PB  - Routledge Journals, Taylor & Francis
SN  - 01635581
KW  - Glucose Metabolism
N2  - The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysiseven in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the -blockers (adrenergic -antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective -blockers have been shown to promote glucose oxidation. Might there be a link?
ER  -

SALAMON, S., E. PODBREGAR, P. KUBATKA, D. BUSSELBERG, M. CAPRNDA, R. OPATRILOVA, V. VALENTOVA, M. ADAMEK, Peter KRUŽLIAK and M. PODBREGAR. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. \textit{Nutrition and cancer : an international journal}. Abingdon: Routledge Journals, Taylor \&{} Francis, 2017, vol.~69, No~2, p.~177-183. ISSN~0163-5581. Available from: https://dx.doi.org/10.1080/01635581.2017.1263751.

Detailed Information on Publication Record