J 2017

C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus

PLESKOVIC, A., M.S. LETONJA, A.C. VUJKOVAC, J.N. STARCEVIC, K. GAZDIKOVA et. al.

Basic information

Original name

C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus

Authors

PLESKOVIC, A. (705 Slovenia), M.S. LETONJA (705 Slovenia), A.C. VUJKOVAC (705 Slovenia), J.N. STARCEVIC (705 Slovenia), K. GAZDIKOVA (703 Slovakia), M. CAPRNDA (703 Slovakia), L. GASPAR (703 Slovakia), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and D. PETROVIOC (705 Slovenia)

Edition

VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE, BERN, VERLAG HANS HUBER HOGREFE AG, 2017, 0301-1526

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.210

RIV identification code

RIV/00216224:14110/17:00098634

Organization unit

Faculty of Medicine

DOI

UT WoS

000400880500006

Keywords in English

Carotid atherosclerosis; inflammation; high sensitive C-reactive protein; prospective study

Tags

Tags

International impact, Reviewed
Změněno: 20/3/2018 16:47, Soňa Böhmová

Abstract

V originále

Background: This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). Patients and methods: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects, with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP >= 2 mg/L and subjects with hs-CRP below 2 mg/L). Results: Subjects with T2DM and hs-CRP levels a 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT, progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. Conclusions: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.