| PLESKOVIC, A., M.S. LETONJA, A.C. VUJKOVAC, J.N. STARCEVIC, K. GAZDIKOVA, M. CAPRNDA, L. GASPAR, Peter KRUŽLIAK and D. PETROVIOC. C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus. VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. BERN: VERLAG HANS HUBER HOGREFE AG, 2017, vol. 46, No 3, p. 187-192. ISSN 0301-1526. Available from: https://dx.doi.org/10.1024/0301-1526/a000614. |
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@article{1398269,
author = {Pleskovic, A. and Letonja, M.S. and Vujkovac, A.C. and Starcevic, J.N. and Gazdikova, K. and Caprnda, M. and Gaspar, L. and Kružliak, Peter and Petrovioc, D.},
article_location = {BERN},
article_number = {3},
doi = {http://dx.doi.org/10.1024/0301-1526/a000614},
keywords = {Carotid atherosclerosis; inflammation; high sensitive C-reactive protein; prospective study},
language = {eng},
issn = {0301-1526},
journal = {VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE},
title = {C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus},
volume = {46},
year = {2017}
}
TY - JOUR
ID - 1398269
AU - Pleskovic, A. - Letonja, M.S. - Vujkovac, A.C. - Starcevic, J.N. - Gazdikova, K. - Caprnda, M. - Gaspar, L. - Kružliak, Peter - Petrovioc, D.
PY - 2017
TI - C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus
JF - VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
VL - 46
IS - 3
SP - 187-192
EP - 187-192
PB - VERLAG HANS HUBER HOGREFE AG
SN - 03011526
KW - Carotid atherosclerosis
KW - inflammation
KW - high sensitive C-reactive protein
KW - prospective study
N2 - Background: This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). Patients and methods: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects, with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP >= 2 mg/L and subjects with hs-CRP below 2 mg/L). Results: Subjects with T2DM and hs-CRP levels a 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT, progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. Conclusions: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.
ER -
PLESKOVIC, A., M.S. LETONJA, A.C. VUJKOVAC, J.N. STARCEVIC, K. GAZDIKOVA, M. CAPRNDA, L. GASPAR, Peter KRUŽLIAK and D. PETROVIOC. C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus. \textit{VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE}. BERN: VERLAG HANS HUBER HOGREFE AG, 2017, vol.~46, No~3, p.~187-192. ISSN~0301-1526. Available from: https://dx.doi.org/10.1024/0301-1526/a000614.
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