Cerium dioxide nanoparticles possess anti-inflammatory
properties in the conditions of the obesity-associated NAFLD in
rats

J 2017

Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

KOBYLIAK, N., O. VIRCHENKO, T. FALALYEYEVA, M. KONDRO, T. BEREGOVA et. al.

Basic information

Original name

Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

Authors

KOBYLIAK, N. (804 Ukraine), O. VIRCHENKO (804 Ukraine), T. FALALYEYEVA (804 Ukraine), M. KONDRO (804 Ukraine), T. BEREGOVA (804 Ukraine), P. BODNAR (804 Ukraine), O. SHCHERBAKOV (804 Ukraine), R. BUBNOV (804 Ukraine), M. CAPRNDA (703 Slovakia), D. DELEV (100 Bulgaria), J. SABO (703 Slovakia), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution), L. RODRIGO (724 Spain), R. OPATRILOVA (203 Czech Republic) and M. SPIVAK (804 Ukraine)

Edition

BIOMEDICINE & PHARMACOTHERAPY, PARIS, ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017, 0753-3322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.457

RIV identification code

RIV/00216224:14110/17:00098635

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.biopha.2017.03.099

UT WoS

000402471000074

Keywords in English

Obesity; Non-alcoholic fatty liver disease (NAFLD); Inflammation; Cytokines; Nanocrystalline cerum dioxide

Abstract

V originále

Background: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO(2)) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. Methods: The study was carried out on three groups of rats: control, MSG- and MSG + nCeO(2). They were injected with saline (control) or MSG. A month after born MSG- rats had been treated with water in a volume of 2.9 ml/kg, MSG + CeO2 groups - with CeO2 intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1 beta, IL-12Bp40, interferon-gamma (INF-gamma)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-beta (TGF-beta)) were measured by ELISA. Results: We have demonstrated the anti- obesity effect of nanocrystalline cerium dioxide and for the first time its anti- inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1 beta, IL-12Bp40) in rat serum and restored the level of anti- inflammatory cytokines (IL-4, IL-10, TGF-beta) to the control values. Conclusion: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti- oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury. (C) 2017 Elsevier Masson SAS. All rights reserved.

Citovat

KOBYLIAK, N., O. VIRCHENKO, T. FALALYEYEVA, M. KONDRO, T. BEREGOVA, P. BODNAR, O. SHCHERBAKOV, R. BUBNOV, M. CAPRNDA, D. DELEV, J. SABO, Peter KRUŽLIAK, L. RODRIGO, R. OPATRILOVA and M. SPIVAK. Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats. BIOMEDICINE & PHARMACOTHERAPY. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017, vol. 90, JUN 2017, p. 608-614. ISSN 0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2017.03.099.

@article{1398270,
   author = {Kobyliak, N. and Virchenko, O. and Falalyeyeva, T. and Kondro, M. and Beregova, T. and Bodnar, P. and Shcherbakov, O. and Bubnov, R. and Caprnda, M. and Delev, D. and Sabo, J. and Kružliak, Peter and Rodrigo, L. and Opatrilova, R. and Spivak, M.},
   article_location = {PARIS},
   article_number = {JUN 2017},
   doi = {http://dx.doi.org/10.1016/j.biopha.2017.03.099},
   keywords = {Obesity; Non-alcoholic fatty liver disease (NAFLD); Inflammation; Cytokines; Nanocrystalline cerum dioxide},
   language = {eng},
   issn = {0753-3322},
   journal = {BIOMEDICINE & PHARMACOTHERAPY},
   title = {Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats},
   volume = {90},
   year = {2017}
}

TY  - JOUR
ID  - 1398270
AU  - Kobyliak, N. - Virchenko, O. - Falalyeyeva, T. - Kondro, M. - Beregova, T. - Bodnar, P. - Shcherbakov, O. - Bubnov, R. - Caprnda, M. - Delev, D. - Sabo, J. - Kružliak, Peter - Rodrigo, L. - Opatrilova, R. - Spivak, M.
PY  - 2017
TI  - Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats
JF  - BIOMEDICINE & PHARMACOTHERAPY
VL  - 90
IS  - JUN 2017
SP  - 608-614
EP  - 608-614
PB  - ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
SN  - 07533322
KW  - Obesity
KW  - Non-alcoholic fatty liver disease (NAFLD)
KW  - Inflammation
KW  - Cytokines
KW  - Nanocrystalline cerum dioxide
N2  - Background: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO(2)) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. Methods: The study was carried out on three groups of rats: control, MSG- and MSG + nCeO(2). They were injected with saline (control) or MSG. A month after born MSG- rats had been treated with water in a volume of 2.9 ml/kg, MSG + CeO2 groups - with CeO2 intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1 beta, IL-12Bp40, interferon-gamma (INF-gamma)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-beta (TGF-beta)) were measured by ELISA. Results: We have demonstrated the anti- obesity effect of nanocrystalline cerium dioxide and for the first time its anti- inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1 beta, IL-12Bp40) in rat serum and restored the level of anti- inflammatory cytokines (IL-4, IL-10, TGF-beta) to the control values. Conclusion: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti- oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury. (C) 2017 Elsevier Masson SAS. All rights reserved.
ER  -

KOBYLIAK, N., O. VIRCHENKO, T. FALALYEYEVA, M. KONDRO, T. BEREGOVA, P. BODNAR, O. SHCHERBAKOV, R. BUBNOV, M. CAPRNDA, D. DELEV, J. SABO, Peter KRUŽLIAK, L. RODRIGO, R. OPATRILOVA and M. SPIVAK. Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats. \textit{BIOMEDICINE \&{}amp; PHARMACOTHERAPY}. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017, vol.~90, JUN 2017, p.~608-614. ISSN~0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2017.03.099.

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