A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis

LIPOVÝ, Břetislav and M. BARAN. A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis. Burns. OXFORD: ELSEVIER SCI LTD, 2017, vol. 43, No 4, p. 890-892. ISSN 0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2017.01.005.

Basic information

Original name

A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis

Authors

LIPOVÝ, Břetislav (203 Czech Republic, guarantor, belonging to the institution) and M. BARAN (703 Slovakia)

Edition

Burns, OXFORD, ELSEVIER SCI LTD, 2017, 0305-4179

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.134

RIV identification code

RIV/00216224:14110/17:00098655

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.burns.2017.01.005

UT WoS

000401884000029

Keywords in English

toxic epidermal necrolysis

Tags

EL OK

Tags

International impact, Reviewed

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Abstract

V originále

Toxic epidermal necrolysis (TEN) is a rare, life-threatening condition, which is caused by the development of massive apoptosis in the dermoepidermal junction [1]. This apoptosis is mainly caused by caspase mechanisms, which are affected by the activity of T-lymphocytes (CD4+ and CD8+), NK cells, or the bond of CD95L to CD95R [2]. Noncaspase mechanisms are also applied in the TEN pathophysiology, e.g., production of granzyme B CD8+ T lymphocytes or NK cells.