LIPOVÝ, Břetislav and M. BARAN. A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis. Burns. OXFORD: ELSEVIER SCI LTD, 2017, vol. 43, No 4, p. 890-892. ISSN 0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2017.01.005.
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Basic information
Original name A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis
Authors LIPOVÝ, Břetislav (203 Czech Republic, guarantor, belonging to the institution) and M. BARAN (703 Slovakia).
Edition Burns, OXFORD, ELSEVIER SCI LTD, 2017, 0305-4179.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30218 General and internal medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.134
RIV identification code RIV/00216224:14110/17:00098655
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.burns.2017.01.005
UT WoS 000401884000029
Keywords in English toxic epidermal necrolysis
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 15/3/2018 17:05.
Abstract
Toxic epidermal necrolysis (TEN) is a rare, life-threatening condition, which is caused by the development of massive apoptosis in the dermoepidermal junction [1]. This apoptosis is mainly caused by caspase mechanisms, which are affected by the activity of T-lymphocytes (CD4+ and CD8+), NK cells, or the bond of CD95L to CD95R [2]. Noncaspase mechanisms are also applied in the TEN pathophysiology, e.g., production of granzyme B CD8+ T lymphocytes or NK cells.
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