| LIPOVÝ, Břetislav, Milena MATEJOVIČOVÁ, H. ŘIHOVÁ, M. ŠTIKAROVSKÁ, Lucie NOVOTNÁ, Miroslava HLAVÁČOVÁ, Hana PAULOVÁ, I. SUCHÁNEK and Pavel BRYCHTA. The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report. Burns Open. Amsterdam: Elsevier, 2017, vol. 1, No 2, p. 80-83. ISSN 2468-9122. Available from: https://dx.doi.org/10.1016/j.burnso.2017.05.007. |
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@article{1398340,
author = {Lipový, Břetislav and Matejovičová, Milena and Řihová, H. and Štikarovská, M. and Novotná, Lucie and Hlaváčová, Miroslava and Paulová, Hana and Suchánek, I. and Brychta, Pavel},
article_location = {Amsterdam},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.burnso.2017.05.007},
keywords = {Toxic epidermal necrolysis; Immunosuppression; Comet assay},
language = {eng},
issn = {2468-9122},
journal = {Burns Open},
title = {The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report},
volume = {1},
year = {2017}
}
TY - JOUR
ID - 1398340
AU - Lipový, Břetislav - Matejovičová, Milena - Řihová, H. - Štikarovská, M. - Novotná, Lucie - Hlaváčová, Miroslava - Paulová, Hana - Suchánek, I. - Brychta, Pavel
PY - 2017
TI - The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report
JF - Burns Open
VL - 1
IS - 2
SP - 80-83
EP - 80-83
PB - Elsevier
SN - 24689122
KW - Toxic epidermal necrolysis
KW - Immunosuppression
KW - Comet assay
N2 - Toxic epidermal necrolysis (TEN) represents the most serious affection within the SCARs group (Severe Cutaneous Adverse Reactions). It is an autoimmune disease manifested by extensive epidermal and mucosal exfoliation. The basic approach in the therapy of patients suffering from toxic epidermal necrolysis is the administration of immunosuppressive medications. Comet assay is a fast, sensitive and relatively easy method used to detect DNA damage levels. We present a case report of a woman with toxic epidermal necrolysis treated with cyclosporine A. During the therapy, comet assay was used to detect the level of DNA damage of circulating lymphocytes and it helped us to reveal qualitative abnormalities in these cells.
ER -
LIPOVÝ, Břetislav, Milena MATEJOVIČOVÁ, H. ŘIHOVÁ, M. ŠTIKAROVSKÁ, Lucie NOVOTNÁ, Miroslava HLAVÁČOVÁ, Hana PAULOVÁ, I. SUCHÁNEK and Pavel BRYCHTA. The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report. \textit{Burns Open}. Amsterdam: Elsevier, 2017, vol.~1, No~2, p.~80-83. ISSN~2468-9122. Available from: https://dx.doi.org/10.1016/j.burnso.2017.05.007.
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