Další formáty:
BibTeX
LaTeX
RIS
@misc{1398360,
author = {Ramana, Pranov and Schejbal, Jan and Adams, Erwin and Augustijns, Patrick and Glatz, Zdeněk and Van Schepdael, Ann},
booktitle = {24th International Symposium on Electro- and Liquid Phase- Separation Techniques - ITP 2017},
keywords = {capillary electrophoresis, magnetic microparticles, IMER, hFMO3},
title = {New IMER setup for metabolic studies in capillary electrophoresis using magnetic microparticles},
year = {2017}
}
TY - SLIDE
ID - 1398360
AU - Ramana, Pranov - Schejbal, Jan - Adams, Erwin - Augustijns, Patrick - Glatz, Zdeněk - Van Schepdael, Ann
PY - 2017
TI - New IMER setup for metabolic studies in capillary electrophoresis using magnetic microparticles
KW - capillary electrophoresis, magnetic microparticles, IMER, hFMO3
N2 - In view of the importance of enzymes in a variety of fields, many efforts were done in the past to study their activity. Especially in drug development, the study of the metabolizing effect of enzymes on new chemical entities is a vital step that should be straightforward to perform in as little time as possible. Sometimes, the enzymes have a rather low stability, in which case a fast enzymatic test is needed. The focus of this work is on the elaboration of an immobilized microenzyme reactor (IMER) that allows an automated survey of the behavior of compounds in the presence of metabolic enzymes. Human flavin containing monooxygenase 3 (hFMO3) was chosen because this enzyme is intrinsically instable, and its immobilization on a solid surface might increase the enzymatic stability.
ER -
RAMANA, Pranov, Jan SCHEJBAL, Erwin ADAMS, Patrick AUGUSTIJNS, Zdeněk GLATZ a Ann VAN SCHEPDAEL. New IMER setup for metabolic studies in capillary electrophoresis using magnetic microparticles. In \textit{24th International Symposium on Electro- and Liquid Phase- Separation Techniques - ITP 2017}. 2017.
|
