The aim of the study was to obtain information about autonomic nervous system (ANS) activity in hematooncological patients in remission before and after the interventional exercise programme through spectral analysis of heart rate variability (HRV). Patients with hematooncological diseases during and after treatment suffer from a number of side effects that aggravate their quality of life. The most common symptom is fatigue which may persist for years after the treatment has ended. The ultimate consequences of fatigue are the limited ability to exercise or to execute a basic mental activity.It is shown that exercise activity in patients with a hematooncological disease can greatly help to reduce fatigue. The non-invasive method of assessing the functional state of the autonomic nervous system was used to assess the effectiveness of the movement intervention by the use of spectral analysis of heart rate variability. The interventional motion programme ran for three months. The programme took place three times a week and lasted 60 minutes. The programme was composed of cardio training, strength training and breathing exercises. The results of the spectral analysis of heart rate variability showed significant positive changes in the autonomic nervous system in the tested group which underwent an interventional motion programme as opposed to a group of patients which did not take part in the programme.