Multi-moral Brain MRI in subjects with PD and iRBD

J 2017

Multi-moral Brain MRI in subjects with PD and iRBD

MANGIA, S., Alena SVÁTKOVÁ, D. MASCALI, M.J. NISSI, P.C. BURTON et. al.

Basic information

Original name

Multi-moral Brain MRI in subjects with PD and iRBD

Authors

MANGIA, S. (840 United States of America), Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution), D. MASCALI (380 Italy), M.J. NISSI (246 Finland), P.C. BURTON (840 United States of America), Petr BEDNAŘÍK (203 Czech Republic, guarantor, belonging to the institution), E.J. AUERBACH (840 United States of America), F. GIOVE (380 Italy), L.E. EBERLY (840 United States of America), M.J. HOWELL (840 United States of America), Igor NESTRAŠIL (203 Czech Republic), P.J. TUITE (380 Italy) and S. MICHAELI (840 United States of America)

Edition

Frontiers in Neuroscience, Lausanne, Frontiers Media S.A. 2017, 1662-453X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.877

RIV identification code

RIV/00216224:14740/17:00098682

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3389/fnins.2017.00709

UT WoS

000418300300002

Keywords in English

rotating frame MRI; Parkinson's disease; iRBD; functional connectivity; DTI

Abstract

V originále

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD. Here we aimed at piloting the characterization of brain tissue properties in mid-brain subcortical regions of 10 healthy subjects, 8 iRBD, and 9 early-diagnosed PD. We used a battery of magnetic resonance imaging (MRI) contrasts at 3T, including adiabatic and non-adiabatic rotating frame techniques developed by our group, along with diffusion tensor imaging (DTI) and resting-state fMRI. Adiabatic T1(rho) and T2(rho), and non-adiabatic RAFF4 (Relaxation Along a Fictitious Field in the rotating frame of rank 4) were found to have lower coefficient of variations and higher sensitivity to detect group differences as compared to DTI parameters such as fractional anisotropy and mean diffusivity. Significantly longer T1(rho) were observed in the amygdala of PD subjects vs. controls, along with a trend of lower functional connectivity as measured by regional homogeneity, thereby supporting the notion that amygdalar dysfunction occurs in PD. Significant abnormalities in reward networks occurred in iRBD subjects, who manifested lower network strength of the accumbens. In agreement with previous studies, significantly longer T1(rho) occurred in the substantia nigra compacta of PD vs. controls, indicative of neuronal degeneration, while regional homogeneity was lower in the substantia nigra reticulata. Finally, other trend-level findings were observed, i.e., lower RAFF4 and T2(rho) in the midbrain of iRBD subjects vs. controls, possibly indicating changes in non-motor features as opposed to motor function in the iRBD group. We conclude that rotating frame relaxation methods along with functional connectivity measures are valuable to characterize iRBD and PD subjects, and with proper validation in larger cohorts may provide pathological signatures of iRBD and PD.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

691110, interní kód MU

Name: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Acronym: MICROBRADAM)

Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Citovat

MANGIA, S., Alena SVÁTKOVÁ, D. MASCALI, M.J. NISSI, P.C. BURTON, Petr BEDNAŘÍK, E.J. AUERBACH, F. GIOVE, L.E. EBERLY, M.J. HOWELL, Igor NESTRAŠIL, P.J. TUITE and S. MICHAELI. Multi-moral Brain MRI in subjects with PD and iRBD (Multi-modal brain MRI in subjects with PD and iRBD). Frontiers in Neuroscience. Lausanne: Frontiers Media S.A., 2017, vol. 11, DEC, p. 709-720. ISSN 1662-453X. Available from: https://dx.doi.org/10.3389/fnins.2017.00709.

@article{1398425,
   author = {Mangia, S. and Svátková, Alena and Mascali, D. and Nissi, M.J. and Burton, P.C. and Bednařík, Petr and Auerbach, E.J. and Giove, F. and Eberly, L.E. and Howell, M.J. and Nestrašil, Igor and Tuite, P.J. and Michaeli, S.},
   article_location = {Lausanne},
   article_number = {DEC},
   doi = {http://dx.doi.org/10.3389/fnins.2017.00709},
   keywords = {rotating frame MRI; Parkinson's disease; iRBD; functional connectivity; DTI},
   language = {eng},
   issn = {1662-453X},
   journal = {Frontiers in Neuroscience},
   title = {Multi-moral Brain MRI in subjects with PD and iRBD},
   url = {https://www.frontiersin.org/articles/10.3389/fnins.2017.00709/full},
   volume = {11},
   year = {2017}
}

TY  - JOUR
ID  - 1398425
AU  - Mangia, S. - Svátková, Alena - Mascali, D. - Nissi, M.J. - Burton, P.C. - Bednařík, Petr - Auerbach, E.J. - Giove, F. - Eberly, L.E. - Howell, M.J. - Nestrašil, Igor - Tuite, P.J. - Michaeli, S.
PY  - 2017
TI  - Multi-moral Brain MRI in subjects with PD and iRBD
JF  - Frontiers in Neuroscience
VL  - 11
IS  - DEC
SP  - 709
EP  - 709
PB  - Frontiers Media S.A.
SN  - 1662453X
KW  - rotating frame MRI
KW  - Parkinson's disease
KW  - iRBD
KW  - functional connectivity
KW  - DTI
UR  - https://www.frontiersin.org/articles/10.3389/fnins.2017.00709/full
L2  - https://www.frontiersin.org/articles/10.3389/fnins.2017.00709/full
N2  - Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD. Here we aimed at piloting the characterization of brain tissue properties in mid-brain subcortical regions of 10 healthy subjects, 8 iRBD, and 9 early-diagnosed PD. We used a battery of magnetic resonance imaging (MRI) contrasts at 3T, including adiabatic and non-adiabatic rotating frame techniques developed by our group, along with diffusion tensor imaging (DTI) and resting-state fMRI. Adiabatic T1(rho) and T2(rho), and non-adiabatic RAFF4 (Relaxation Along a Fictitious Field in the rotating frame of rank 4) were found to have lower coefficient of variations and higher sensitivity to detect group differences as compared to DTI parameters such as fractional anisotropy and mean diffusivity. Significantly longer T1(rho) were observed in the amygdala of PD subjects vs. controls, along with a trend of lower functional connectivity as measured by regional homogeneity, thereby supporting the notion that amygdalar dysfunction occurs in PD. Significant abnormalities in reward networks occurred in iRBD subjects, who manifested lower network strength of the accumbens. In agreement with previous studies, significantly longer T1(rho) occurred in the substantia nigra compacta of PD vs. controls, indicative of neuronal degeneration, while regional homogeneity was lower in the substantia nigra reticulata. Finally, other trend-level findings were observed, i.e., lower RAFF4 and T2(rho) in the midbrain of iRBD subjects vs. controls, possibly indicating changes in non-motor features as opposed to motor function in the iRBD group. We conclude that rotating frame relaxation methods along with functional connectivity measures are valuable to characterize iRBD and PD subjects, and with proper validation in larger cohorts may provide pathological signatures of iRBD and PD.
ER  -

MANGIA, S., Alena SVÁTKOVÁ, D. MASCALI, M.J. NISSI, P.C. BURTON, Petr BEDNAŘÍK, E.J. AUERBACH, F. GIOVE, L.E. EBERLY, M.J. HOWELL, Igor NESTRAŠIL, P.J. TUITE and S. MICHAELI. Multi-moral Brain MRI in subjects with PD and iRBD (Multi-modal brain MRI in subjects with PD and iRBD). \textit{Frontiers in Neuroscience}. Lausanne: Frontiers Media S.A., 2017, vol.~11, DEC, p.~709-720. ISSN~1662-453X. Available from: https://dx.doi.org/10.3389/fnins.2017.00709.

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