Post-WBRT cognitive impairment and hippocampal neuronal
depletion measured by in vivo metabolic MR spectroscopy:
Results of prospective investigational study

J 2017

Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

POSPÍŠIL, Petr, Tomáš KAZDA, Ludmila HYNKOVÁ, Martin BULIK, M. DOBIASKOVA et. al.

Basic information

Original name

Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

Authors

POSPÍŠIL, Petr (203 Czech Republic, guarantor, belonging to the institution), Tomáš KAZDA (203 Czech Republic, belonging to the institution), Ludmila HYNKOVÁ (203 Czech Republic, belonging to the institution), Martin BULIK (203 Czech Republic), M. DOBIASKOVA (203 Czech Republic), Petr BURKOŇ (203 Czech Republic, belonging to the institution), N.N. LAACK (840 United States of America), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution) and Radim JANČÁLEK (203 Czech Republic, belonging to the institution)

Edition

Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology, Barcelona, Elsevier, 2017, 0167-8140

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.942

RIV identification code

RIV/00216224:14110/17:00098708

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.radonc.2016.12.013

UT WoS

000397691500008

Keywords in English

Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy

Abstract

V originále

Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. Material and methods: Thirty-five patients with brain metastases underwent baseline single slice multivoxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10 x 3.0 Gy, 6 MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. Results: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42 mM; -12.9%, 95%Cl: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60 mM; -12%, 95%Cl: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Delta-14.1 +/- 20.3 points in transformed 0100 point scale; p = 0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r = +0.32; p = 0.24) as well as with AVLT_DR (r = +0.33; p = 0.22) decline. Changes in right htNAA/Cr negatively correlated with AVLT_DR (r = -0.48; p = 0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. Conclusions: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy. 2016 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 122 (2017) 373-379

Citovat

POSPÍŠIL, Petr, Tomáš KAZDA, Ludmila HYNKOVÁ, Martin BULIK, M. DOBIASKOVA, Petr BURKOŇ, N.N. LAACK, Pavel ŠLAMPA and Radim JANČÁLEK. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology. Barcelona: Elsevier, 2017, vol. 122, No 3, p. 373-379. ISSN 0167-8140. Available from: https://dx.doi.org/10.1016/j.radonc.2016.12.013.

@article{1398895,
   author = {Pospíšil, Petr and Kazda, Tomáš and Hynková, Ludmila and Bulik, Martin and Dobiaskova, M. and Burkoň, Petr and Laack, N.N. and Šlampa, Pavel and Jančálek, Radim},
   article_location = {Barcelona},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.radonc.2016.12.013},
   keywords = {Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy},
   language = {eng},
   issn = {0167-8140},
   journal = {Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology},
   title = {Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study},
   volume = {122},
   year = {2017}
}

TY  - JOUR
ID  - 1398895
AU  - Pospíšil, Petr - Kazda, Tomáš - Hynková, Ludmila - Bulik, Martin - Dobiaskova, M. - Burkoň, Petr - Laack, N.N. - Šlampa, Pavel - Jančálek, Radim
PY  - 2017
TI  - Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study
JF  - Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology
VL  - 122
IS  - 3
SP  - 373-379
EP  - 373-379
PB  - Elsevier
SN  - 01678140
KW  - Hippocampus
KW  - Radiation injury
KW  - Neurocognitive function
KW  - Magnetic resonance spectroscopy
N2  - Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. Material and methods: Thirty-five patients with brain metastases underwent baseline single slice multivoxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10 x 3.0 Gy, 6 MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. Results: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42 mM; -12.9%, 95%Cl: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60 mM; -12%, 95%Cl: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Delta-14.1 +/- 20.3 points in transformed 0100 point scale; p = 0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r = +0.32; p = 0.24) as well as with AVLT_DR (r = +0.33; p = 0.22) decline. Changes in right htNAA/Cr negatively correlated with AVLT_DR (r = -0.48; p = 0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. Conclusions: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy. 2016 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 122 (2017) 373-379
ER  -

POSPÍŠIL, Petr, Tomáš KAZDA, Ludmila HYNKOVÁ, Martin BULIK, M. DOBIASKOVA, Petr BURKOŇ, N.N. LAACK, Pavel ŠLAMPA and Radim JANČÁLEK. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. \textit{Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology}. Barcelona: Elsevier, 2017, vol.~122, No~3, p.~373-379. ISSN~0167-8140. Available from: https://dx.doi.org/10.1016/j.radonc.2016.12.013.

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