Patterns of failure after brain metastases radiotherapy:
reflections on the importance for treatment and clinical trials
reporting

J 2017

Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting

LAKOMÝ, Radek, Ludmila HYNKOVÁ, Petr POSPÍŠIL, Petr BURKOŇ, Marek SLÁVIK et. al.

Basic information

Original name

Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting

Authors

LAKOMÝ, Radek (203 Czech Republic, belonging to the institution), Ludmila HYNKOVÁ (203 Czech Republic, belonging to the institution), Petr POSPÍŠIL (203 Czech Republic, belonging to the institution), Petr BURKOŇ (203 Czech Republic, belonging to the institution), Marek SLÁVIK (703 Slovakia, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution), Radim JANČÁLEK (203 Czech Republic, belonging to the institution) and Tomáš KAZDA (203 Czech Republic, belonging to the institution)

Edition

Neoplasma, BRATISLAVA, Slovenská akademie vied, 2017, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.696

RIV identification code

RIV/00216224:14110/17:00098709

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/neo_2017_302

UT WoS

000402095500002

Keywords in English

progression; brain recurrence; stereotactic radiosurgery; whole brain radiotherapy; hippocampal sparing radiotherapy

Abstract

V originále

In many ongoing clinical trials, new strategies for radiotherapy of brain metastases are currently being investigated. A post surgical focal cavity stereotactic radiosurgery and the developing role of a hippocampal-sparing whole brain radiotherapy are of the highest importance. The evaluation of spatial patterns of metastases failure after radiotherapy is a powerful tool for assessing the potential benefit of new different radiotherapy approaches, which enables to identify possible directions leading to better radiotherapy techniques and to modify general management for newly diagnosed brain metastases. The purpose of this article is to present a mix between trial data and philosophical point of view for discussion about the importance of systematic evaluation of spatial patterns of failure in all ongoing trials investigating new approaches in local brain metastases treatment.

Citovat

LAKOMÝ, Radek, Ludmila HYNKOVÁ, Petr POSPÍŠIL, Petr BURKOŇ, Marek SLÁVIK, Pavel ŠLAMPA, Radim JANČÁLEK and Tomáš KAZDA. Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting. Neoplasma. BRATISLAVA: Slovenská akademie vied, 2017, vol. 64, No 3, p. 329-337. ISSN 0028-2685. Available from: https://dx.doi.org/10.4149/neo_2017_302.

@article{1398897,
   author = {Lakomý, Radek and Hynková, Ludmila and Pospíšil, Petr and Burkoň, Petr and Slávik, Marek and Šlampa, Pavel and Jančálek, Radim and Kazda, Tomáš},
   article_location = {BRATISLAVA},
   article_number = {3},
   doi = {http://dx.doi.org/10.4149/neo_2017_302},
   keywords = {progression; brain recurrence; stereotactic radiosurgery; whole brain radiotherapy; hippocampal sparing radiotherapy},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting},
   volume = {64},
   year = {2017}
}

TY  - JOUR
ID  - 1398897
AU  - Lakomý, Radek - Hynková, Ludmila - Pospíšil, Petr - Burkoň, Petr - Slávik, Marek - Šlampa, Pavel - Jančálek, Radim - Kazda, Tomáš
PY  - 2017
TI  - Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting
JF  - Neoplasma
VL  - 64
IS  - 3
SP  - 329-337
EP  - 329-337
PB  - Slovenská akademie vied
SN  - 00282685
KW  - progression
KW  - brain recurrence
KW  - stereotactic radiosurgery
KW  - whole brain radiotherapy
KW  - hippocampal sparing radiotherapy
N2  - In many ongoing clinical trials, new strategies for radiotherapy of brain metastases are currently being investigated. A post surgical focal cavity stereotactic radiosurgery and the developing role of a hippocampal-sparing whole brain radiotherapy are of the highest importance. The evaluation of spatial patterns of metastases failure after radiotherapy is a powerful tool for assessing the potential benefit of new different radiotherapy approaches, which enables to identify possible directions leading to better radiotherapy techniques and to modify general management for newly diagnosed brain metastases. The purpose of this article is to present a mix between trial data and philosophical point of view for discussion about the importance of systematic evaluation of spatial patterns of failure in all ongoing trials investigating new approaches in local brain metastases treatment.
ER  -

LAKOMÝ, Radek, Ludmila HYNKOVÁ, Petr POSPÍŠIL, Petr BURKOŇ, Marek SLÁVIK, Pavel ŠLAMPA, Radim JANČÁLEK and Tomáš KAZDA. Patterns of failure after brain metastases radiotherapy: reflections on the importance for treatment and clinical trials reporting. \textit{Neoplasma}. BRATISLAVA: Slovenská akademie vied, 2017, vol.~64, No~3, p.~329-337. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2017\_{}302.

Detailed Information on Publication Record