| ARSENEAULT, M., J. MONLONG, N.S. VASUDEV, R.S. LASKAR, M. SAFISAMGHABADI, P. HARNDEN, L. EGEVAD, N. NOURBEHESHT, P. PANICHNANTAKUL, I. HOLCATOVA, A. BRISUDA, V. JANOUT, H. KOLLAROVA, Lenka FORETOVÁ, M. NAVRATILOVA, D. MATES, V. JINGA, D. ZARIDZE, A. MUKERIA, P. JANDAGHI, P. BRENNAN, A. BRAZMA, J. TOST, G. SCELO, R.E. BANKS, M. LATHROP, G. BOURQUE and Y. RIAZALHOSSEINI. Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, 2017, vol. 7, No 44876, p. 1-8. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/srep44876. |
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@article{1398985,
author = {Arseneault, M. and Monlong, J. and Vasudev, N.S. and Laskar, R.S. and Safisamghabadi, M. and Harnden, P. and Egevad, L. and Nourbehesht, N. and Panichnantakul, P. and Holcatova, I. and Brisuda, A. and Janout, V. and Kollarova, H. and Foretová, Lenka and Navratilova, M. and Mates, D. and Jinga, V. and Zaridze, D. and Mukeria, A. and Jandaghi, P. and Brennan, P. and Brazma, A. and Tost, J. and Scelo, G. and Banks, R.E. and Lathrop, M. and Bourque, G. and Riazalhosseini, Y.},
article_location = {LONDON},
article_number = {44876},
doi = {http://dx.doi.org/10.1038/srep44876},
keywords = {KDM5D; KDM6C},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma},
volume = {7},
year = {2017}
}
TY - JOUR
ID - 1398985
AU - Arseneault, M. - Monlong, J. - Vasudev, N.S. - Laskar, R.S. - Safisamghabadi, M. - Harnden, P. - Egevad, L. - Nourbehesht, N. - Panichnantakul, P. - Holcatova, I. - Brisuda, A. - Janout, V. - Kollarova, H. - Foretová, Lenka - Navratilova, M. - Mates, D. - Jinga, V. - Zaridze, D. - Mukeria, A. - Jandaghi, P. - Brennan, P. - Brazma, A. - Tost, J. - Scelo, G. - Banks, R.E. - Lathrop, M. - Bourque, G. - Riazalhosseini, Y.
PY - 2017
TI - Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma
JF - Scientific Reports
VL - 7
IS - 44876
SP - 1-8
EP - 1-8
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - KDM5D
KW - KDM6C
N2 - Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17.1%). Furthermore, somatic loss of chromosome Y (LOY) was detected in about 40% of male subjects, while mosaic LOY was detected in DNA isolated from peripheral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples. LOY in constitutional DNA, but not in tumor DNA was associated with older age. Amongst Y-linked genes that were downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency is involved in ccRCC progression. Our findings establish somatic LOY as a highly recurrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest that different mechanisms may underlie the somatic and mosaic LOY observed in tumors and peripheral blood, respectively.
ER -
ARSENEAULT, M., J. MONLONG, N.S. VASUDEV, R.S. LASKAR, M. SAFISAMGHABADI, P. HARNDEN, L. EGEVAD, N. NOURBEHESHT, P. PANICHNANTAKUL, I. HOLCATOVA, A. BRISUDA, V. JANOUT, H. KOLLAROVA, Lenka FORETOVÁ, M. NAVRATILOVA, D. MATES, V. JINGA, D. ZARIDZE, A. MUKERIA, P. JANDAGHI, P. BRENNAN, A. BRAZMA, J. TOST, G. SCELO, R.E. BANKS, M. LATHROP, G. BOURQUE and Y. RIAZALHOSSEINI. Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. \textit{Scientific Reports}. LONDON: NATURE PUBLISHING GROUP, 2017, vol.~7, No~44876, p.~1-8. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/srep44876.
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