Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes
in a Pooled Analysis of Case-Control Studies

J 2017

Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies

OLSSON, A.C., R. VERMEULEN, J. SCHUZ, H. KROMHOUT, B. PESCH et. al.

Basic information

Original name

Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies

Authors

OLSSON, A.C. (250 France), R. VERMEULEN (528 Netherlands), J. SCHUZ (250 France), H. KROMHOUT (528 Netherlands), B. PESCH (276 Germany), S. PETERS (250 France), T. BEHRENS (276 Germany), L. PORTENGEN (250 France), D. MIRABELLI (752 Sweden), P. GUSTAVSSON (752 Sweden), B. KENDZIA (276 Germany), J. ALMANSA (528 Netherlands), V. LUZON (250 France), J. VLAANDEREN (250 France), I. STUCKER (250 France), F. GUIDA (250 France), D. CONSONNI (380 Italy), N. CAPORASO (840 United States of America), M.T. LANDI (840 United States of America), J. FIELD (826 United Kingdom of Great Britain and Northern Ireland), I. BRUSKE (276 Germany), H.E. WICHMANN (276 Germany), J. SIEMIATYCKI (124 Canada), M.E. PARENT (124 Canada), L. RICHIARDI (380 Italy), F. MERLETTI (380 Italy), K.H. JOCKEL (276 Germany), W. AHRENS (276 Germany), H. POHLABELN (276 Germany), N. PLATO (752 Sweden), A. TARDON (724 Spain), D. ZARIDZE (643 Russian Federation), J. MCLAUGHLIN (124 Canada), P. DEMERS (124 Canada), N. SZESZENIA-DABROWSKA (616 Poland), J. LISSOWSKA (616 Poland), P. RUDNAI (348 Hungary), E. FABIANOVA (703 Slovakia), R.S. DUMITRU (642 Romania), V. BENCKO (203 Czech Republic), Lenka FORETOVÁ (203 Czech Republic, guarantor, belonging to the institution), V. JANOUT (203 Czech Republic), P. BOFFETTA (840 United States of America), B. BUENO-DE-MESQUITA (528 Netherlands), F. FORASTIERE (380 Italy), T. BRUNING (276 Germany) and K. STRAIF (250 France)

Edition

Epidemiology, Philadelphia (USA), Lippincott Williams and Wilkins, 2017, 1044-3983

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30305 Occupational health

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.991

RIV identification code

RIV/00216224:14110/17:00098731

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1097/EDE.0000000000000604

UT WoS

000393959000027

Keywords in English

Lung Cancer

Abstract

V originále

Background: Evidence is limited regarding risk and the shape of the exposure-response curve at low asbestos exposure levels. We estimated the exposure-response for occupational asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies. Methods: We pooled 14 case-control studies conducted in 19852010 in Europe and Canada, including 17,705 lung cancer cases and 21,813 controls with detailed information on tobacco habits and lifetime occupations. We developed a quantitative job-exposure-matrix to estimate job-, time period-, and region-specific exposure levels. Fiber-years (ff/ml-years) were calculated for each subject by linking the matrix with individual occupational histories. We fit unconditional logistic regression models to estimate odds ratios (ORs), 95% confidence intervals (CIs), and trends. Results: The fully adjusted OR for ever-exposure to asbestos was 1.24 (95% CI, 1.18, 1.31) in men and 1.12 (95% CI, 0.95, 1.31) in women. In men, increasing lung cancer risk was observed with increasing exposure in all smoking categories and for all three major lung cancer subtypes. In women, lung cancer risk for all subtypes was increased in current smokers (ORs similar to two-fold). The joint effect of asbestos exposure and smoking did not deviate from multiplicativity among men, and was more than additive among women. Conclusions: Our results in men showed an excess risk of lung cancer and its subtypes at low cumulative exposure levels, with a steeper exposure-response slope in this exposure range than at higher, previously studied levels. (See video abstract at, http://links.lww.com/EDE/B161.)

Citovat

OLSSON, A.C., R. VERMEULEN, J. SCHUZ, H. KROMHOUT, B. PESCH, S. PETERS, T. BEHRENS, L. PORTENGEN, D. MIRABELLI, P. GUSTAVSSON, B. KENDZIA, J. ALMANSA, V. LUZON, J. VLAANDEREN, I. STUCKER, F. GUIDA, D. CONSONNI, N. CAPORASO, M.T. LANDI, J. FIELD, I. BRUSKE, H.E. WICHMANN, J. SIEMIATYCKI, M.E. PARENT, L. RICHIARDI, F. MERLETTI, K.H. JOCKEL, W. AHRENS, H. POHLABELN, N. PLATO, A. TARDON, D. ZARIDZE, J. MCLAUGHLIN, P. DEMERS, N. SZESZENIA-DABROWSKA, J. LISSOWSKA, P. RUDNAI, E. FABIANOVA, R.S. DUMITRU, V. BENCKO, Lenka FORETOVÁ, V. JANOUT, P. BOFFETTA, B. BUENO-DE-MESQUITA, F. FORASTIERE, T. BRUNING and K. STRAIF. Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies. Epidemiology. Philadelphia (USA): Lippincott Williams and Wilkins, 2017, vol. 28, No 2, p. 288-299. ISSN 1044-3983. Available from: https://dx.doi.org/10.1097/EDE.0000000000000604.

@article{1398986,
   author = {Olsson, A.C. and Vermeulen, R. and Schuz, J. and Kromhout, H. and Pesch, B. and Peters, S. and Behrens, T. and Portengen, L. and Mirabelli, D. and Gustavsson, P. and Kendzia, B. and Almansa, J. and Luzon, V. and Vlaanderen, J. and Stucker, I. and Guida, F. and Consonni, D. and Caporaso, N. and Landi, M.T. and Field, J. and Bruske, I. and Wichmann, H.E. and Siemiatycki, J. and Parent, M.E. and Richiardi, L. and Merletti, F. and Jockel, K.H. and Ahrens, W. and Pohlabeln, H. and Plato, N. and Tardon, A. and Zaridze, D. and McLaughlin, J. and Demers, P. and SzeszeniaandDabrowska, N. and Lissowska, J. and Rudnai, P. and Fabianova, E. and Dumitru, R.S. and Bencko, V. and Foretová, Lenka and Janout, V. and Boffetta, P. and BuenoandDeandMesquita, B. and Forastiere, F. and Bruning, T. and Straif, K.},
   article_location = {Philadelphia (USA)},
   article_number = {2},
   doi = {http://dx.doi.org/10.1097/EDE.0000000000000604},
   keywords = {Lung Cancer},
   language = {eng},
   issn = {1044-3983},
   journal = {Epidemiology},
   title = {Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies},
   volume = {28},
   year = {2017}
}

TY  - JOUR
ID  - 1398986
AU  - Olsson, A.C. - Vermeulen, R. - Schuz, J. - Kromhout, H. - Pesch, B. - Peters, S. - Behrens, T. - Portengen, L. - Mirabelli, D. - Gustavsson, P. - Kendzia, B. - Almansa, J. - Luzon, V. - Vlaanderen, J. - Stucker, I. - Guida, F. - Consonni, D. - Caporaso, N. - Landi, M.T. - Field, J. - Bruske, I. - Wichmann, H.E. - Siemiatycki, J. - Parent, M.E. - Richiardi, L. - Merletti, F. - Jockel, K.H. - Ahrens, W. - Pohlabeln, H. - Plato, N. - Tardon, A. - Zaridze, D. - McLaughlin, J. - Demers, P. - Szeszenia-Dabrowska, N. - Lissowska, J. - Rudnai, P. - Fabianova, E. - Dumitru, R.S. - Bencko, V. - Foretová, Lenka - Janout, V. - Boffetta, P. - Bueno-De-Mesquita, B. - Forastiere, F. - Bruning, T. - Straif, K.
PY  - 2017
TI  - Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies
JF  - Epidemiology
VL  - 28
IS  - 2
SP  - 288-299
EP  - 288-299
PB  - Lippincott Williams and Wilkins
SN  - 10443983
KW  - Lung Cancer
N2  - Background: Evidence is limited regarding risk and the shape of the exposure-response curve at low asbestos exposure levels. We estimated the exposure-response for occupational asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies. Methods: We pooled 14 case-control studies conducted in 19852010 in Europe and Canada, including 17,705 lung cancer cases and 21,813 controls with detailed information on tobacco habits and lifetime occupations. We developed a quantitative job-exposure-matrix to estimate job-, time period-, and region-specific exposure levels. Fiber-years (ff/ml-years) were calculated for each subject by linking the matrix with individual occupational histories. We fit unconditional logistic regression models to estimate odds ratios (ORs), 95% confidence intervals (CIs), and trends. Results: The fully adjusted OR for ever-exposure to asbestos was 1.24 (95% CI, 1.18, 1.31) in men and 1.12 (95% CI, 0.95, 1.31) in women. In men, increasing lung cancer risk was observed with increasing exposure in all smoking categories and for all three major lung cancer subtypes. In women, lung cancer risk for all subtypes was increased in current smokers (ORs similar to two-fold). The joint effect of asbestos exposure and smoking did not deviate from multiplicativity among men, and was more than additive among women. Conclusions: Our results in men showed an excess risk of lung cancer and its subtypes at low cumulative exposure levels, with a steeper exposure-response slope in this exposure range than at higher, previously studied levels. (See video abstract at, http://links.lww.com/EDE/B161.)
ER  -

OLSSON, A.C., R. VERMEULEN, J. SCHUZ, H. KROMHOUT, B. PESCH, S. PETERS, T. BEHRENS, L. PORTENGEN, D. MIRABELLI, P. GUSTAVSSON, B. KENDZIA, J. ALMANSA, V. LUZON, J. VLAANDEREN, I. STUCKER, F. GUIDA, D. CONSONNI, N. CAPORASO, M.T. LANDI, J. FIELD, I. BRUSKE, H.E. WICHMANN, J. SIEMIATYCKI, M.E. PARENT, L. RICHIARDI, F. MERLETTI, K.H. JOCKEL, W. AHRENS, H. POHLABELN, N. PLATO, A. TARDON, D. ZARIDZE, J. MCLAUGHLIN, P. DEMERS, N. SZESZENIA-DABROWSKA, J. LISSOWSKA, P. RUDNAI, E. FABIANOVA, R.S. DUMITRU, V. BENCKO, Lenka FORETOVÁ, V. JANOUT, P. BOFFETTA, B. BUENO-DE-MESQUITA, F. FORASTIERE, T. BRUNING and K. STRAIF. Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies. \textit{Epidemiology}. Philadelphia (USA): Lippincott Williams and Wilkins, 2017, vol.~28, No~2, p.~288-299. ISSN~1044-3983. Available from: https://dx.doi.org/10.1097/EDE.0000000000000604.

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