Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes

PAVLOVÁ, Tereza, Filip ZLÁMAL, Zbyněk ŠPLÍCHAL, Josef TOMANDL, Zuzana HODICKÁ, Pavel VENTRUBA and Julie BIENERTOVÁ VAŠKŮ. Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. LONDON: INFORMA HEALTHCARE, 2018, vol. 31, No 14, p. 1811-1818. ISSN 1476-7058. Available from: https://dx.doi.org/10.1080/14767058.2017.1328493.

Basic information

• Original name: Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes
• Authors: PAVLOVÁ, Tereza (203 Czech Republic, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Zuzana HODICKÁ (203 Czech Republic), Pavel VENTRUBA (203 Czech Republic) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution).
• Edition: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30214 Obstetrics and gynaecology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.569
• RIV identification code: RIV/00216224:14110/18:00102133
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1080/14767058.2017.1328493
• UT WoS: 000430732700001
• Keywords in English: Visfatin; PBEF; NAMPT; preterm birth; preterm premature rupture of membranes
• Tags: 14110512, 14110518, EL OK, podil, rivok
• Tags: International impact, Reviewed

Abstract

Objectives: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within seven days and after more than seven days following admission for PTB/preterm premature rupture of membranes (PPROMs).Methods: Maternal peripheral blood and cord blood were collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (three with PPROM).Results: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p=.021) and also in mothers who delivered within seven days after admission for PTB or PPROM, compared to those who delivered after more than seven days (p=.027; p=.039). Cord blood visfatin concentration was found to be decreased in preterm compared to term infants (p=.007).Conclusions: Visfatin in both maternal and fetal circulation may play an important role in the pathogenesis of PTB/PPROM and could be used to distinguish between women who will deliver in a short period of time after clinical presentation of PTB/PPROM and those who deliver later. Nevertheless, additional research is necessary in order to identify its direct involvement in PTB/PPROM.

Links

• EF15_003/0000469, research and development project: Name: Cetocoen Plus
• LM2015051, research and development project: Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR