J 2018

Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes

PAVLOVÁ, Tereza, Filip ZLÁMAL, Zbyněk ŠPLÍCHAL, Josef TOMANDL, Zuzana HODICKÁ et. al.

Basic information

Original name

Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes

Authors

PAVLOVÁ, Tereza (203 Czech Republic, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Zuzana HODICKÁ (203 Czech Republic), Pavel VENTRUBA (203 Czech Republic) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.569

RIV identification code

RIV/00216224:14110/18:00102133

Organization unit

Faculty of Medicine

DOI

UT WoS

000430732700001

Keywords in English

Visfatin; PBEF; NAMPT; preterm birth; preterm premature rupture of membranes

Tags

Tags

International impact, Reviewed
Změněno: 26/3/2019 10:35, Soňa Böhmová

Abstract

V originále

Objectives: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within seven days and after more than seven days following admission for PTB/preterm premature rupture of membranes (PPROMs).Methods: Maternal peripheral blood and cord blood were collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (three with PPROM).Results: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p=.021) and also in mothers who delivered within seven days after admission for PTB or PPROM, compared to those who delivered after more than seven days (p=.027; p=.039). Cord blood visfatin concentration was found to be decreased in preterm compared to term infants (p=.007).Conclusions: Visfatin in both maternal and fetal circulation may play an important role in the pathogenesis of PTB/PPROM and could be used to distinguish between women who will deliver in a short period of time after clinical presentation of PTB/PPROM and those who deliver later. Nevertheless, additional research is necessary in order to identify its direct involvement in PTB/PPROM.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR